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题目:: Active-MMP2 in cancer cell nests of oral cancer patients: correlation with lymph node metastasis.
作者:: Kawamata(H),Uchida(D),Hamano(H),Kimura-Yanagawa(T),Nakashiro(K I),Hino(S),Omotehara(F),Yoshida(H),Sato(M)
状态:: 发布时间1998-12-09 , 更新时间 2006-11-15
期刊:: Int J Oncol
摘要:: We examined the gelatinolytic activity in human oral squamous-cell carcinoma tissues in order to evaluate the capability of intravasation and extravasation of cancer cells. By a microdissection-zymography, we demonstrated separately the gelatinolytic activities in cancer cell nests and stroma adjacent to the cancer cells. The gelatinolytic activities, such as pro-matrix metalloproteinase (MMP)9 and active-MMP2 in most of cancer cell nests were much higher than those of normal gingival epithelium. Moreover, the activities of active-MMP2 in cancer cell nests of metastatic cancers were significantly higher than those of non-metastatic cancers (p<0.05). These results suggest that active-MMP2 in cancer cells can be a predictive marker for metastasis formation in oral squamous-cell carcinoma patients.
语言:: eng
DOI:

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