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PMID: 9707642 Published · ppublish English Journal Article

Genetically engineered broad-spectrum disease resistance in tomato.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 17 ·1998-08-18 ·Pages 10300-5

Oldroyd GE, Staskawicz BJ

Abstract

Resistance in tomato to the bacterial pathogen Pseudomonas syringae pathovar tomato requires Pto and Prf. Mutations that eliminate Prf show a loss of both Pto resistance and sensitivity to the organophosphate insecticide fenthion, suggesting that Prf controls both phenotypes. Herein, we report that the overexpression of Prf leads to enhanced resistance to a number of normally virulent bacterial and viral pathogens and leads to increased sensitivity to fenthion. These plants express levels of salicylic acid comparable to plants induced for systemic acquired resistance (SAR) and constitutively express pathogenesis related genes. These results suggest that the overexpression of Prf activates the Pto and Fen pathways in a pathogen-independent manner and leads to the activation of SAR. Transgene-induced SAR has implications for the generation of broad spectrum disease resistance in agricultural crop plants.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oldroyd G E
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720-3102, USA.
Staskawicz B J
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.17.10300
Published
1998-08-18
Pages
10300-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC21503
External Links
PubMed source DOI: 10.1073/pnas.95.17.10300 PMC Full Text View journal details
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