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PMID: 96878 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability.

Biological psychiatry ·Vol. 13 ·No. 2 ·1978-04-00 ·Pages 283-90

Griffiths RR, Brady JV, Snell JD

Abstract

A quantitative ratio measure was developed which permitted comparisons between the reinforcing and anorectic potency of eight phenylethylamine anorectics and cocaine in laboratory baboons. The ordering of these compounds based upon this ratio bears a reasonable correspondence to clinical drug evaluations. The measure may provide information for preclinical evaluation of relative abuse potential of anorectic drugs.

MeSH Terms

Animals Appetite/drug effects Appetite Depressants/pharmacology Chlorphentermine/pharmacology Cocaine/pharmacology Dextroamphetamine/pharmacology Diethylpropion/pharmacology Dose-Response Relationship, Drug Fenfluramine/pharmacology Haplorhini Humans Papio Phenethylamines/pharmacology Phenmetrazine/pharmacology Phentermine/pharmacology Phenylpropanolamine/pharmacology Reinforcement, Psychology Substance-Related Disorders/prevention & control

Chemicals

Appetite Depressants Phenethylamines Fenfluramine Phenylpropanolamine Phentermine Cocaine Chlorphentermine Diethylpropion Dextroamphetamine Phenmetrazine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Griffiths R R

Brady J V

Snell J D

Article Info

Journal

Biological psychiatry

Abbr.

Biol Psychiatry

ISSN

0006-3223

Published

1978-04-00

Pages

283-90

Language

English

Region

United States

NLM ID

0213264

Subset

External Links

PubMed source View journal details

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Relationship between anorectic and reinforcing properties of appetite suppressant drugs: implications for assessment of abuse liability.

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