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PMID: 9685265 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.

Science (New York, N.Y.) ·Vol. 281 ·No. 5377 ·1998-07-31 ·Pages 703-6

Gross DM, Forsthuber T, Tary-Lehmann M, Etling C, Ito K, Nagy ZA, Field JA, Steere AC, Huber BT

Abstract

Treatment-resistant Lyme arthritis is associated with immune reactivity to outer surface protein A (OspA) of Borrelia burgdorferi, the agent of Lyme disease, and the major histocompatibility complex class II allele DRB1*0401. The immunodominant epitope of OspA for T helper cells was identified. A homology search revealed a peptide from human leukocyte function-associated antigen-1 (hLFA-1) as a candidate autoantigen. Individuals with treatment-resistant Lyme arthritis, but not other forms of arthritis, generated responses to OspA, hLFA-1, and their highly related peptide epitopes. Identification of the initiating bacterial antigen and a cross-reactive autoantigen may provide a model for development of autoimmune disease.

MeSH Terms

Adolescent Adult Algorithms Amino Acid Sequence Animals Antigen Presentation Antigens, Surface/immunology,metabolism Arthritis, Reactive/drug therapy,immunology Autoantigens/immunology Autoimmune Diseases/immunology Bacterial Outer Membrane Proteins/immunology,metabolism Bacterial Vaccines Borrelia burgdorferi Group/immunology Child Cross Reactions Female HLA-DR Antigens/genetics,immunology,metabolism HLA-DRB1 Chains Humans Immunodominant Epitopes Lipoproteins Lyme Disease/drug therapy,immunology Lymphocyte Function-Associated Antigen-1/chemistry,immunology,metabolism Male Mice Mice, Transgenic Molecular Sequence Data Synovial Fluid/immunology T-Lymphocytes, Helper-Inducer/immunology

Chemicals

Antigens, Surface Autoantigens Bacterial Outer Membrane Proteins Bacterial Vaccines HLA-DR Antigens HLA-DRB1 Chains HLA-DRB1*04:01 antigen Immunodominant Epitopes Lipoproteins Lymphocyte Function-Associated Antigen-1 OspA protein

Authors & Affiliations

9 authors, click to expand affiliations / ORCID

Gross D M

Department of Pathology, Tufts University, Boston, MA 02111 USA.

Forsthuber T

Tary-Lehmann M

Etling C

Ito K

Nagy Z A

Field J A

Steere A C

Huber B T

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.281.5377.703

Published

1998-07-31

Pages

703-6

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAMS NIH HHS · R01 AR20358 · United States

Corrections

CommentIn

PMID: 9714671

External Links

PubMed source DOI: 10.1126/science.281.5377.703 View journal details

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Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis.

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