Home LiteratureArticle Details

PMID: 968486 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza.

Science (New York, N.Y.) ·Vol. 194 ·No. 4262 ·1976-10-15 ·Pages 334-5

Palese P, Ritchey MB, Schulman JL, Kilbourne ED

Abstract

Analysis of the RNA migration pattern of a high-yielding influenza virus recombinant, X-53, used in vaccine production, reveals that only the two genes coding for hemagglutinin and neuraminidase antigens were derived from the "swine" influenza virus parent. A/New Jersey/11/76, while six were acquired from the A/PR/8/34 (HON1) parent, donor of the high yield characteristic.

MeSH Terms

Antigens, Viral/analysis Genes Hemagglutinins, Viral/analysis Hybridization, Genetic Influenza A virus/analysis,immunology Neuraminidase/immunology,metabolism Orthomyxoviridae/analysis RNA, Viral/analysis Viral Proteins/metabolism Virus Cultivation

Chemicals

Antigens, Viral Hemagglutinins, Viral RNA, Viral Viral Proteins Neuraminidase

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Palese P

Ritchey M B

Schulman J L

Kilbourne E D

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.968486

Published

1976-10-15

Pages

334-5

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.968486 View journal details

Analysis Services

Genetic composition of a high-yielding influenza A virus recombinant: a vaccine strain against "Swine" influenza.

Contact

WeChat Official Account