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PMID: 9684281 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Epithelial carcinogenesis in the mouse: correlating the genetics and the biology.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences ·Vol. 353 ·No. 1370 ·1998-06-29 ·Pages 839-45

Frame S, Crombie R, Liddell J, Stuart D, Linardopoulos S, Nagase H, Portella G, Brown K, Street A, Akhurst R, Balmain A

Abstract

Tumour formation relies on a complex combination of genetic and environmental factors. In particular, the contributions from inherited predisposition genes as well as carcinogens, for example from cigarettes or in the diet, are amongst the major contributors to tumorigenesis. Since the study of such processes in particularly difficult in human cancers, the availability of a well-defined model system is of obvious benefit. The mouse skin model of multistage carcinogenesis offers an excellent tool for the study of the target cells, the target genes and the biological events associated with neoplasia. In this system, tumorigenesis occurs in a series of defined stages, each of which is characterized by specific and reproducible alterations in genes such as H-ras, cyclin D1, p53 and p16INK4A. Additional changes occur in the production of, or response to, factors such as transforming growth factor beta (TGF beta). These genetic and biological alterations are mirrored in human tumours of epithelial origin. Hence, research into the general principles of tumour initiation, promotion and progression in the context of the mouse skin model is likely to prove valuable in the continual search for new methods for the diagnosis, prevention, and therapeutic treatment of human cancers.

MeSH Terms
Animals Cell Cycle Cell Transformation, Neoplastic Cyclin D1/genetics DNA Damage Epithelial Cells/cytology,pathology Genes, p16 Genes, p53 Genes, ras Humans Mice Models, Biological Neoplasms/genetics,pathology,physiopathology Neoplasms, Experimental/genetics,pathology,physiopathology
Chemicals
Cyclin D1
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Frame S
CRC Beatson Laboratories, Department of Medical Oncology, Glasgow, UK.
Crombie R
Liddell J
Stuart D
Linardopoulos S
Nagase H
Portella G
Brown K
Street A
Akhurst R
Balmain A
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Article Info
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Abbr.
Philos Trans R Soc Lond B Biol Sci
ISSN
0962-8436
DOI
10.1098/rstb.1998.0248
Published
1998-06-29
Pages
839-45
Language
English
Region
England
NLM ID
7503623
PMCID
PMC1692278
Subset
IM
External Links
PubMed source DOI: 10.1098/rstb.1998.0248 PMC Full Text View journal details
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