In utero programming of chronic disease.

Clinical science (London, England : 1979) ·Vol. 95 ·No. 2 ·1998-08-00 ·Pages 115-28

Barker DJ

Abstract

1. Many human fetuses have to adapt to a limited supply of nutrients. In doing so they permanently change their structure and metabolism. 2. These 'programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders stroke, diabetes and hypertension. 3. This review examines the evidence linking these diseases to fetal undernutrition and provides an overview of previous studies in this area.

MeSH Terms

Child Child, Preschool Chronic Disease Coronary Disease/etiology Diabetes Mellitus, Type 2/etiology Embryonic and Fetal Development/physiology Female Fetal Growth Retardation/metabolism Humans Hypertension/etiology Infant, Newborn Male Middle Aged Placental Insufficiency/metabolism Pregnancy Prenatal Exposure Delayed Effects

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Barker D J

MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, U.K.

Article Info

Journal

Clinical science (London, England : 1979)

Abbr.

Clin Sci (Lond)

ISSN

0143-5221

Published

1998-08-00

Pages

115-28

Language

English

Region

England

NLM ID

7905731

Subset

External Links

PubMed source View journal details

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In utero programming of chronic disease.

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