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题目:: Quantitative analysis of CDKN2, p53 and retinoblastoma mRNA in human gastric carcinoma.
作者:: Chen(Y J),Shih(L S),Chen(Y M)
状态:: 发布时间1998-08-14 , 更新时间 2005-11-17
期刊:: Int J Oncol
摘要:: The mRNA level of CDKN2 (p16), retinoblastoma (Rb) and p53 in cancerous and non-cancerous tissue samples were compared using a semi-quantitative reverse-transcription-polymerase chain reaction method. The mean CDKN2 mRNA level of 10 gastric cancer specimens was significantly higher than that of their non-cancerous tissue samples (p=0.039). In contrast, the mRNA levels of Rb and p53 in gastric cancer tissues were both significantly lower than those in their non-cancerous tissue samples. Furthermore, both mRNA ratios of Rb/CDKN2 and p53/CDKN2 were significantly decreased in gastric cancer tissues. Therefore, suppression of both Rb and p53 and overexpression of CDKN2 may be associated with the tumorigenesis of gastric cancer.
语言:: eng
DOI:

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