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PMID: 9658022 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Opposing roles of the Staphylococcus aureus virulence regulators, Agr and Sar, in Triton X-100- and penicillin-induced autolysis.

Journal of bacteriology ·Vol. 180 ·No. 14 ·1998-07-00 ·Pages 3724-6

Fujimoto DF, Bayles KW

Abstract

The regulation of murein hydrolases is a critical aspect of peptidoglycan growth and metabolism. In the present study, we demonstrate that mutations within the Staphylococcus aureus virulence factor regulatory genes, agr and sar, affect autolysis, resulting in decreased and increased autolysis rates, respectively. Zymographic analyses of these mutant strains suggest that agr and sar exert their effects on autolysis, in part, by modulating murein hydrolase expression and/or activity.

MeSH Terms
Bacterial Proteins/physiology Bacteriolysis/drug effects Excipients GTP-Binding Proteins/physiology Monomeric GTP-Binding Proteins Octoxynol Penicillins Peptidoglycan/biosynthesis,metabolism Staphylococcus aureus/drug effects,pathogenicity Trans-Activators Transcription Factors/physiology Virulence
Chemicals
Agr protein, Staphylococcus aureus Bacterial Proteins Excipients Penicillins Peptidoglycan SAR protein, Lycopersicon esculentum Trans-Activators Transcription Factors Octoxynol GTP-Binding Proteins Monomeric GTP-Binding Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Fujimoto D F
Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, Idaho 83844-3052, USA.
Bayles K W
References (15)
15 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.180.14.3724-3726.1998
Published
1998-07-00
Pages
3724-6
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC107347
Subset
IM
Grants
NIAID NIH HHS · R29 AI038901 · United States
NIAID NIH HHS · R29AI38901 · United States
External Links
PubMed source DOI: 10.1128/JB.180.14.3724-3726.1998 PMC Full Text View journal details
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