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PMID: 9638370 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.

Current opinion in immunology ·Vol. 10 ·No. 3 ·1998-06-00 ·Pages 330-6

Abraham RT

Abstract

Recent findings have significantly advanced our understanding of the mechanism by which the potent immunosuppressive drug rapamycin inhibits cytokine-dependent lymphocyte proliferation. The protein targeted by the immunophilin-rapamycin complex is a member of a newly defined family of phosphoinositide-3-kinase-related kinases. The rapamycin target protein functions as a protein kinase in a signal transduction pathway that regulates the synthesis of proteins required for cell-cycle progression in both lymphoid and nonlymphoid cells.

MeSH Terms

3-Phosphoinositide-Dependent Protein Kinases Adaptor Proteins, Signal Transducing Animals Carrier Proteins/drug effects,physiology Cell Cycle Proteins/biosynthesis,genetics Cell Survival DNA-Binding Proteins/drug effects,physiology Enzyme Activation Eukaryotic Initiation Factors Fungal Proteins/genetics,physiology Gene Expression Regulation/physiology Growth Substances/physiology Heat-Shock Proteins/drug effects,physiology Immunosuppressive Agents/pharmacology Mice Models, Immunological Multigene Family Phosphatidylinositol 3-Kinases Phosphoproteins/metabolism Phosphotransferases (Alcohol Group Acceptor)/genetics,physiology Polyenes/pharmacology Protein Kinases Protein Serine-Threonine Kinases/chemistry Saccharomyces cerevisiae/drug effects,genetics Saccharomyces cerevisiae Proteins Signal Transduction/physiology Sirolimus TOR Serine-Threonine Kinases Tacrolimus/pharmacology Tacrolimus Binding Proteins

Chemicals

Adaptor Proteins, Signal Transducing Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins EIF4EBP1 protein, human Eif4ebp1 protein, mouse Eukaryotic Initiation Factors Fungal Proteins Growth Substances Heat-Shock Proteins Immunosuppressive Agents Phosphoproteins Polyenes Saccharomyces cerevisiae Proteins Protein Kinases Phosphotransferases (Alcohol Group Acceptor) MTOR protein, human mTOR protein, mouse TOR1 protein, S cerevisiae TOR2 protein, S cerevisiae 3-Phosphoinositide-Dependent Protein Kinases Protein Serine-Threonine Kinases TOR Serine-Threonine Kinases Tacrolimus Binding Proteins Sirolimus Tacrolimus

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Abraham R T

Division of Oncology Research, Mayo Clinic, Rochester, Minnesota 55905, USA. abraham.robert@mayo.edu

Article Info

Journal

Current opinion in immunology

Abbr.

Curr Opin Immunol

ISSN

0952-7915

DOI

10.1016/s0952-7915(98)80172-6

abraham.robert@mayo.edu

Published

1998-06-00

Pages

330-6

Language

English

Region

England

NLM ID

8900118

Subset

Grants

NCI NIH HHS · CA76193 · United States

External Links

PubMed source DOI: 10.1016/s0952-7915(98)80172-6 View journal details

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Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine receptor signaling.

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