Nucleocytoplasmic transport: driving and directing transport.

Current biology : CB ·Vol. 8 ·No. 11 ·1998-05-21 ·Pages R368-72

Cole CN, Hammell CM

Abstract

Nucleocytoplasmic transport involves assembly and movement across the nuclear envelope of cargo-receptor complexes that interact with the small GTPase Ran. The asymmetric distribution of Ran regulator proteins, RanGAP1 and RCC1, provides the driving force and directionality for nuclear transport.

MeSH Terms

Animals Biological Transport, Active Carrier Proteins/metabolism Cell Cycle Proteins Cell Nucleus/metabolism Cytoplasm/metabolism DNA-Binding Proteins/metabolism GTP Phosphohydrolases/metabolism GTPase-Activating Proteins Guanine Nucleotide Exchange Factors Guanosine Diphosphate/metabolism Guanosine Triphosphate/metabolism Models, Biological Nuclear Proteins/metabolism Saccharomyces cerevisiae/metabolism ran GTP-Binding Protein

Chemicals

Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins GTPase-Activating Proteins Guanine Nucleotide Exchange Factors Nuclear Proteins RCC1 protein, human Guanosine Diphosphate Guanosine Triphosphate GTP Phosphohydrolases ran GTP-Binding Protein

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cole C N

Department of Biochemistry, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. charles.cole@dartmouth.edu

Hammell C M

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(98)70239-8

charles.cole@dartmouth.edu

Published

1998-05-21

Pages

R368-72

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(98)70239-8 View journal details

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