Home LiteratureArticle Details
PMID: 9632381 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The HIV-1 envelope glycoproteins: fusogens, antigens, and immunogens.

Science (New York, N.Y.) ·Vol. 280 ·No. 5371 ·1998-06-19 ·Pages 1884-8

Wyatt R, Sodroski J

Abstract

The human immunodeficiency virus-type 1 (HIV-1) envelope glycoproteins interact with receptors on the target cell and mediate virus entry by fusing the viral and cell membranes. The structure of the envelope glycoproteins has evolved to fulfill these functions while evading the neutralizing antibody response. An understanding of the viral strategies for immune evasion should guide attempts to improve the immunogenicity of the HIV-1 envelope glycoproteins and, ultimately, aid in HIV-1 vaccine development.

MeSH Terms
AIDS Vaccines/chemistry,immunology Animals Gene Products, env/chemistry,immunology,physiology HIV Antibodies/biosynthesis HIV Antigens/immunology HIV Envelope Protein gp41/physiology HIV Infections/immunology HIV-1/chemistry,immunology,physiology Humans Membrane Fusion Receptors, HIV/metabolism
Chemicals
AIDS Vaccines Gene Products, env HIV Antibodies HIV Antigens HIV Envelope Protein gp41 Receptors, HIV
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wyatt R
Department of Cancer Immunology/AIDS, Dana-Farber Cancer Institute, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Sodroski J
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.280.5371.1884
Published
1998-06-19
Pages
1884-8
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NIAID NIH HHS · AI 31783 · United States
NIAID NIH HHS · AI 39420 · United States
NIAID NIH HHS · AI28691 · United States
External Links
PubMed source DOI: 10.1126/science.280.5371.1884 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2