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PMID: 963202 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Computer simulation of movement-generating cross-bridges.

Biophysical journal ·Vol. 16 ·No. 9 ·1976-09-00 ·Pages 1013-27

Brokaw CJ

Abstract

A stochastic computational method was developed to study properties of cross-bridge models for muscle contraction, by following the time history of individual cross-bridge model of Andrew Huxley (1957) and a modified two-state model with more realistic behavior during steady stretching are used as examples. The method can readily compute steady-state force during shortening and stretching and force-transients following rapid changes in length. Computations of velocity with a steady load and of velocity transients are more sensitive to the randomness inherent in the stochastic method.

MeSH Terms
Computers Mathematics Models, Biological Muscle Contraction
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Brokaw C J
References (12)
12 references, click to expand
  1. Muscle structure and theories of contraction.
    Prog Biophys Biophys Chem. 1957;7:255-318 PMID: 13485191
  2. Theoretical formalism for the sliding filament model of contraction of striated muscle. Part I.
    Prog Biophys Mol Biol. 1974;28:267-340 PMID: 4617248
  3. On the theory of ion transport across the nerve membrane, VII. Cooperativity between channels of a large square lattice.
    Proc Natl Acad Sci U S A. 1973 Jan;70(1):62-5 PMID: 4509665
  4. A model for the transient and steady-state mechanical behavior of contracting muscle.
    Biophys J. 1974 Jul;14(7):546-62 PMID: 4836669
  5. Computer simulation of flagellar movement. I. Demonstration of stable bend propagation and bend initiation by the sliding filament model.
    Biophys J. 1972 May;12(5):564-86 PMID: 5030565
  6. Proposed mechanism of force generation in striated muscle.
    Nature. 1971 Oct 22;233(5321):533-8 PMID: 4939977
  7. Muscle filament structure and muscle contraction.
    Annu Rev Biophys Bioeng. 1975;4(00):137-63 PMID: 1098552
  8. Very high tension with very little ATP breakdown by active skeletal muscle.
    J Mechanochem Cell Motil. 1975;3(2):147-54 PMID: 1082485
  9. Molecular mechanism for oscillation in flagella and muscle.
    Proc Natl Acad Sci U S A. 1975 Aug;72(8):3102-6 PMID: 1059095
  10. Some self-consistent two-state sliding filament models of muscle contraction.
    Biophys J. 1975 Apr;15(4):335-72 PMID: 1125390
  11. Theoretical formalism for the sliding filament model of contraction of striated muscle. Part II.
    Prog Biophys Mol Biol. 1975;29(2):105-59 PMID: 1135417
  12. A comparison of coherent averaging techniques for repetitive biological signals.
    Med Res Eng. 1969 Aug-Sep;8(4):22-6 PMID: 5823260
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(76)85752-9
Published
1976-09-00
Pages
1013-27
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1334942
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(76)85752-9 PMC Full Text View journal details
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