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PMID: 962877 Published · ppublish English Journal Article

Methods for fitting equations with two or more non-linear parameters.

The Biochemical journal ·Vol. 157 ·No. 2 ·1976-08-01 ·Pages 489-92

Nimmo IA, Atkins GL

Abstract

1. Descriptions are given of two ways for fitting non-linear equations by least-squares criteria to experimental data. One depends on solving a set of non-linear simultaneous equations, and the other on Taylor's theorem. 2. It is shown that better parameter estimates result when an equation with two or more non-linear parameters is fitted to all the sets of data simultaneously than when it is fitted to each set in turn.

MeSH Terms
Enzymes Kinetics Models, Biological Statistics as Topic
Chemicals
Enzymes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nimmo I A
Atkins G L
References (7)
7 references, click to expand
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  3. Use of progress curves to investigate product inhibition in enzyme-catalysed reactions. Application to the soluble mitochondrial adenosine triphosphatase.
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    Eur J Biochem. 1974 Apr 1;43(2):377-8 PMID: 4838986
  5. A simple digital-computer program for estimating the parameters of the hill equation.
    Eur J Biochem. 1973 Feb 15;33(1):175-80 PMID: 4691349
  6. The statistical analysis of enzyme kinetic data.
    Adv Enzymol Relat Areas Mol Biol. 1967;29:1-32 PMID: 4881884
  7. A comparison of seven methods for fitting the Michaelis-Menten equation.
    Biochem J. 1975 Sep;149(3):775-7 PMID: 1201002
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
Published
1976-08-01
Pages
489-92
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1163877
Subset
IM
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