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PMID: 9624486 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Comparison of in vitro antifungal activities of free and liposome-encapsulated nystatin with those of four amphotericin B formulations.

Antimicrobial agents and chemotherapy ·Vol. 42 ·No. 6 ·1998-06-00 ·Pages 1412-6

Johnson EM, Ojwang JO, Szekely A, Wallace TL, Warnock DW

Abstract

The in vitro activity of a multilamellar liposomal formulation of nystatin (Nyotran) was compared with those of free nystatin and four pharmaceutical preparations of amphotericin B. MICs for 200 isolates of two Aspergillus spp., seven Candida spp., and Cryptococcus neoformans were determined by a broth microdilution adaptation of the method recommended by the National Committee for Clinical Laboratory Standards. Minimum lethal concentrations (MLCs) of the six antifungal preparations were also determined. Both nystatin formulations possessed fungistatic and fungicidal activities against the 10 species tested. Liposomal nystatin appeared to be as active as free nystatin, with MICs and MLCs that were similar to, or lower than, those of the latter. Neither formulation of nystatin was as active as amphotericin B deoxycholate (Fungizone) or amphotericin B lipid complex (Abelcet), but both were more effective than liposomal amphotericin B (AmBisome). Our results suggest that further evaluation of liposomal nystatin is justified.

MeSH Terms
Amphotericin B/pharmacology Antifungal Agents/chemistry,pharmacology Aspergillus/drug effects Candida/drug effects Cryptococcus neoformans/drug effects Drug Carriers Liposomes Microbial Sensitivity Tests Nystatin/chemistry,pharmacology
Chemicals
Antifungal Agents Drug Carriers Liposomes Nystatin Amphotericin B
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Johnson E M
Mycology Reference Laboratory, Public Health Laboratory Service, Bristol, United Kingdom.
Ojwang J O
Szekely A
Wallace T L
Warnock D W
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.42.6.1412
Published
1998-06-00
Pages
1412-6
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC105614
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.42.6.1412 PMC Full Text View journal details
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