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PMID: 9603849 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Culture conditions control expression of the genes for aflatoxin and sterigmatocystin biosynthesis in Aspergillus parasiticus and A. nidulans.

Applied and environmental microbiology ·Vol. 64 ·No. 6 ·1998-06-00 ·Pages 2275-7

Feng GH, Leonard TJ

Abstract

High temperature and nitrate supported gene expression for sterigmatocystin biosynthesis in Aspergillus nidulans; ammonium did not. Homologous genes for aflatoxin biosynthesis in A. parasiticus showed the opposite transcript expression pattern, suggesting that the two mycotoxins are regulated differently. The aflR gene is postulated to require additional genetic elements to effect its own activation by the different culture conditions. A patulin polyketide synthase (PKS) gene was found to be regulated differently than the aflatoxin PKS. Thus, the biosyntheses of structurally similar compounds in these two fungi appear to be regulated very differently.

MeSH Terms
Aflatoxins/biosynthesis,genetics Aspergillus/genetics,metabolism Aspergillus nidulans/genetics,metabolism DNA, Fungal/genetics Gene Expression Regulation, Fungal Genes, Fungal Molecular Sequence Data Multienzyme Complexes/genetics Nitrates/metabolism Quaternary Ammonium Compounds/metabolism Species Specificity Sterigmatocystin/biosynthesis Temperature
Chemicals
Aflatoxins DNA, Fungal Multienzyme Complexes Nitrates Quaternary Ammonium Compounds Sterigmatocystin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Feng G H
Department of Genetics, University of Wisconsin, Madison, Wisconsin 53706, USA.
Leonard T J
References (13)
13 references, click to expand
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Article Info
Journal
Applied and environmental microbiology
Abbr.
Appl Environ Microbiol
ISSN
0099-2240
DOI
10.1128/AEM.64.6.2275-2277.1998
Published
1998-06-00
Pages
2275-7
Language
English
Region
United States
NLM ID
7605801
PMCID
PMC106313
Subset
IM
Databases
GENBANK
U52151
External Links
PubMed source DOI: 10.1128/AEM.64.6.2275-2277.1998 PMC Full Text View journal details
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