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PMID: 959817 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cholera toxin-peroxidase: changes in surface labeling of glioblastoma cells with increased time in tissue culture.

Science (New York, N.Y.) ·Vol. 193 ·No. 4253 ·1976-08-13 ·Pages 587-8

Skaper SD, Willis RC, Seegmiller JE

Abstract

Cholera toxin coupled to peroxidase yielded a highly specific ultrastructural marker of plasma membrane monosialogangliosides. Studies with cultures of brain and brain tumors suggested that long-term culture of tissue in monolayers results in eventual loss of surface monosialogangliosides.

MeSH Terms

Cell Line Cell Membrane/metabolism Gangliosides/metabolism Glioma/metabolism,pathology Peroxidases Time Factors Toxins, Biological/metabolism Vibrio cholerae

Chemicals

Gangliosides Toxins, Biological Peroxidases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Skaper S D

Willis R C

Seegmiller J E

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.959817

Published

1976-08-13

Pages

587-8

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.959817 View journal details

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Cholera toxin-peroxidase: changes in surface labeling of glioblastoma cells with increased time in tissue culture.

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