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PMID: 9596770 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Goldfish, Carassius auratus, a novel animal model for the study of Mycobacterium marinum pathogenesis.

Infection and immunity ·Vol. 66 ·No. 6 ·1998-06-00 ·Pages 2938-42

Talaat AM, Reimschuessel R, Wasserman SS, Trucksis M

Abstract

We have developed an animal model for studying mycobacterial pathogenesis using Mycobacterium marinum and the goldfish, Carassius auratus. Goldfish are injected intraperitoneally with doses between 10(2) and 10(9) CFU of M. marinum organisms. Depending on the dose of M. marinum organisms administered, an acute or chronic disease is produced. The acute disease is characterized by systemic mycobacterial infection, severe peritonitis, tissue necrosis, and a short median survival time. The chronic disease is characterized by granuloma formation in all organs and survival of animals to the end point of the experiment (56 days). Colony counts in organ homogenates showed recovery of mycobacteria from a high percentage of inoculated animals. We believe this well-characterized animal model will be useful for studying mycobacterial pathogenesis.

MeSH Terms
Acute Disease Animals Chronic Disease Disease Models, Animal Fish Diseases/etiology Goldfish Granuloma/etiology,pathology,veterinary Kidney/microbiology,pathology Liver/microbiology,pathology Mycobacterium Infections, Nontuberculous/veterinary Mycobacterium marinum/pathogenicity Species Specificity Spleen/microbiology,pathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Talaat A M
Center for Vaccine Development, Division of Geographic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Reimschuessel R
Wasserman S S
Trucksis M
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.66.6.2938-2942.1998
Published
1998-06-00
Pages
2938-42
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC108292
Subset
IM
External Links
PubMed source DOI: 10.1128/IAI.66.6.2938-2942.1998 PMC Full Text View journal details
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