[Observation of the invasion of retinoblastoma cells to the corneal epithelial cells and keratocytes in culture].
作者:
Li(Y),Feng(G),Yi(Y)
状态:
发布时间1998-05-26
, 更新时间 2006-11-15
期刊:
Zhonghua Yan Ke Za Zhi
摘要:
To study the invasive ability of retinoblastoma cells into the corneal epithelial cells and keratocytes in culture.,SO-Rb50 cells of retinoblastoma, corneal epithelial cells and keratocytes were co-cultured. The morphological changes of SO-Rb50 cells adherent to the corneal epithelial cells and keratocytes were observed. The distribution of proteoglycans in the SO-Rb50 cells, corneal cells and keratocytes was analyzed by histochemical method and electron microscopy.,SO-Rb50 cells could adhere to the keratocytes, but did not adhere to the corneal epithelial cells. There are common hyaluronidase-resistant and chondroitinase-resistant proteoglycans on the surface of SO-Rb50 cells and corneal epithelial cells. Chondroitin is present on the surface of keratocytes.,It is considered that the cell surface proteoglycans may play an important role in mediating SO-Rb50 tumor cell adhesion and non-adhesion to normal cells.