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PMID: 956725 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Association of serum hemolytic complement levels with the major histocompatibility complex in chickens.

The Journal of experimental medicine ·Vol. 144 ·No. 2 ·1976-08-01 ·Pages 555-61

Chanh TC, Benedict AA, Abplanalp H

Abstract

The total hemolytic complement (C) levels in inbred line 7 chicks and adults were lower than C levels in inbred lines 2 and 3 and in outbred chickens of the same age. In all birds, adult levels of C were obtained in 5- to 6-wk-old chickens. Analysis of F1 and F3 generations clearly showed that the C level in chickens was determined by a dominant gene(s) associated with the major histocompatibility complex. Finding this association in a nonmammal strengthens the importance of the relationship between closely linked genes controlling histocompatibility, immune responsiveness, mixed leukocyte reaction, and C activity.

MeSH Terms

Age Factors Animals Chickens/immunology Complement System Proteins Genes, Dominant Genetic Linkage Histocompatibility Antigens

Chemicals

Histocompatibility Antigens Complement System Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Chanh T C

Benedict A A

Abplanalp H

References (14)

14 references, click to expand

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Evidence for an association between immune responsiveness of chicken to (T, G)-A--L and the major histocompatibility system.
Eur J Immunol. 1974 Aug;4(8):548-53 PMID: 4413330
Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement.
J Exp Med. 1974 Oct 1;140(4):1108-11 PMID: 4427089
Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system.
J Exp Med. 1975 May 1;141(5):1216-20 PMID: 805206
H-2 linked Ss protein is C4 component of complement.
Nature. 1975 Nov 20;258(5532):243-5 PMID: 1202351
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Nature. 1975 Nov 20;258(5532):242-3 PMID: 1202350
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Adv Exp Med Biol. 1975;64:467-78 PMID: 1199884
Genetic control of immune responses in chickens.
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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.144.2.555

Published

1976-08-01

Pages

555-61

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2190379

Subset

External Links

PubMed source DOI: 10.1084/jem.144.2.555 PMC Full Text View journal details

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Association of serum hemolytic complement levels with the major histocompatibility complex in chickens.

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