Changes in presynaptic protein NACP/alpha-synuclein in an ischemic gerbil hippocampus.

Brain research ·Vol. 788 ·No. 1-2 ·1998-03-30 ·Pages 311-4

Ishimaru H, Uéda K, Takahashi A, Maruyama Y

Abstract

We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP-positive unusual tubal and chain-like structures developed on month 6. We suggest that the changes in NACP may play an important role in the ischemic pathogenesis.

MeSH Terms

Amyloid/metabolism Animals Gerbillinae Hippocampus/blood supply,metabolism Immunohistochemistry Ischemic Attack, Transient/metabolism Male Nerve Tissue Proteins/metabolism Presynaptic Terminals/metabolism Protein Precursors/metabolism Synucleins alpha-Synuclein

Chemicals

Amyloid Nerve Tissue Proteins Protein Precursors Synucleins alpha-Synuclein

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Ishimaru H

Department of Neuropsychopharmacology (Tsumura), Gunma University School of Medicine, Maebashi-shi, Gunma 371, Japan. ishimaru@news.sb.gunma-u.ac.jp

Uéda K

Takahashi A

Maruyama Y

Article Info

Journal

Brain research

Abbr.

Brain Res

ISSN

0006-8993

DOI

10.1016/s0006-8993(98)00033-x

ishimaru@news.sb.gunma-u.ac.jp

Published

1998-03-30

Pages

311-4

Language

English

Region

Netherlands

NLM ID

0045503

Subset

External Links

PubMed source DOI: 10.1016/s0006-8993(98)00033-x View journal details

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Changes in presynaptic protein NACP/alpha-synuclein in an ischemic gerbil hippocampus.

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