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PMID: 9552350 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The role of RB in cell cycle control.

Progress in cell cycle research ·Vol. 1 ·1995-00-00 ·Pages 9-19

Hatakeyama M, Weinberg RA

Abstract

The retinoblastoma protein is an inhibitor of cell cycle progression from the G1 to the S phase of the cell cycle. It acts through its ability to interact with cellular target molecules such as E2F transcription factors. The function of pRB is negatively regulated by a cell-cycle dependent phosphorylation catalyzed by cyclin-dependent kinases in the late G1 cell cycle phase. Recent evidence indicates that this pRB inactivation is a key molecular event leading to the S-phase commitment at the G1 restriction point in the cell cycle. Deregulated inactivation of pRB in G1 phase may be a universal mechanism underlying cellular transformation.

MeSH Terms

Animals Apoptosis/physiology Cell Cycle/physiology Cell Cycle Proteins Cell Transformation, Neoplastic Cyclin D Cyclin E/metabolism Cyclin-Dependent Kinase Inhibitor p21 Cyclin-Dependent Kinase Inhibitor p27 Cyclins/metabolism,physiology Discoidin Domain Receptor 1 Fungal Proteins/metabolism G1 Phase/physiology Gene Expression Regulation Mammals/physiology Mice Mice, Knockout Microtubule-Associated Proteins/physiology Models, Biological Phosphorylation Protein Processing, Post-Translational Protein-Tyrosine Kinases/metabolism Receptor Protein-Tyrosine Kinases/physiology Retinoblastoma Protein/physiology S Phase/physiology Saccharomyces cerevisiae/cytology,metabolism Signal Transduction Tumor Suppressor Proteins

Chemicals

Cdkn1a protein, mouse Cdkn1b protein, mouse Cell Cycle Proteins Cyclin D Cyclin E Cyclin-Dependent Kinase Inhibitor p21 Cyclins Fungal Proteins Microtubule-Associated Proteins Retinoblastoma Protein Tumor Suppressor Proteins Cyclin-Dependent Kinase Inhibitor p27 DDR1 protein, human Discoidin Domain Receptor 1 Protein-Tyrosine Kinases Receptor Protein-Tyrosine Kinases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Hatakeyama M

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142, USA.

Weinberg R A

Article Info

Journal

Progress in cell cycle research

Abbr.

Prog Cell Cycle Res

ISSN

1087-2957

DOI

10.1007/978-1-4615-1809-9_2

Published

1995-00-00

Pages

9-19

Language

English

Region

France

NLM ID

9609058

Subset

External Links

PubMed source DOI: 10.1007/978-1-4615-1809-9_2

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