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PMID: 9548448 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Suppression of anti-microtubule agent-induced apoptosis by nitric oxide: possible mechanism of a new drug resistance.

Japanese journal of cancer research : Gann ·Vol. 89 ·No. 2 ·1998-02-00 ·Pages 199-205

Ogura T, DeGeorge G, Tatemichi M, Esumi H

Abstract

The propensity of a cell to undergo apoptosis has been proposed to be a determinant of sensitivity to anti-microtubule agents. The anti-microtubule agents vincristine and paclitaxel induce key features of apoptosis, such as intranucleosomal DNA fragmentation and changes in nuclear morphology in the human neuroblastoma cell line, NB-39-nu. Nitric oxide (NO) generated from NO-releasing drugs prevented anti-microtubule agent-induced apoptosis in this cell line. The mechanism of suppression of apoptosis by NO appears to be via the inhibition of an interleukin-1beta converting enzyme-like protease cascade. This finding reveals a new biological function of NO, as well as a new molecular insight into resistance to chemotherapy with anti-microtubule agents.

MeSH Terms
Antineoplastic Agents, Phytogenic/pharmacology Apoptosis/drug effects,physiology Caspase 1 Cysteine Endopeptidases/metabolism Drug Resistance, Neoplasm Enzyme Activation Enzyme Inhibitors/pharmacokinetics,pharmacology Humans Microtubules/drug effects Neuroblastoma/drug therapy,enzymology,pathology Nitric Oxide/pharmacology Paclitaxel/pharmacology Penicillamine/analogs & derivatives,pharmacokinetics,pharmacology S-Nitroso-N-Acetylpenicillamine Tumor Cells, Cultured/drug effects Vincristine/pharmacology
Chemicals
Antineoplastic Agents, Phytogenic Enzyme Inhibitors Nitric Oxide Vincristine S-Nitroso-N-Acetylpenicillamine Cysteine Endopeptidases Caspase 1 Penicillamine Paclitaxel
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ogura T
Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Chiba.
DeGeorge G
Tatemichi M
Esumi H
References (34)
34 references, click to expand
  1. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds.
    Mol Pharmacol. 1995 Apr;47(4):757-65 PMID: 7723736
  2. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked.
    Science. 1997 Feb 21;275(5303):1129-32 PMID: 9027314
  3. Multidrug resistance.
    J Natl Cancer Inst. 1988 Mar 2;80(1):14-20 PMID: 2892943
  4. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation.
    Cell. 1994 Dec 30;79(7):1137-46 PMID: 7528106
  5. Protease activation during apoptosis: death by a thousand cuts?
    Cell. 1995 Aug 11;82(3):349-52 PMID: 7634323
  6. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.
    Cell. 1996 Jul 12;86(1):147-57 PMID: 8689682
  7. Chondrocyte apoptosis induced by nitric oxide.
    Am J Pathol. 1995 Jan;146(1):75-85 PMID: 7856740
  8. Resistance to apoptotic cell death in a drug resistant T cell leukaemia cell line.
    Leukemia. 1996 Mar;10(3):447-55 PMID: 8642860
  9. Nitric oxide induces apoptosis in mouse thymocytes.
    J Immunol. 1995 Sep 15;155(6):2858-65 PMID: 7673702
  10. Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells.
    Mol Pharmacol. 1995 Jun;47(6):1106-11 PMID: 7603448
  11. Specific expression of the ret proto-oncogene in human neuroblastoma cell lines.
    Oncogene. 1990 Sep;5(9):1291-6 PMID: 2216455
  12. Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic RINm5F cells.
    Exp Cell Res. 1994 Jul;213(1):172-7 PMID: 8020588
  13. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action.
    Biochim Biophys Acta. 1993 Aug 18;1178(2):153-75 PMID: 7688574
  14. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases.
    J Exp Med. 1997 Feb 17;185(4):601-7 PMID: 9034139
  15. bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs.
    Cancer Res. 1992 Oct 1;52(19):5407-11 PMID: 1394146
  16. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.
    Science. 1997 Feb 21;275(5303):1132-6 PMID: 9027315
  17. High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.
    Leukemia. 1994 Nov;8(11):1960-9 PMID: 7526093
  18. Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism.
    J Neurosci. 1996 Apr 1;16(7):2325-34 PMID: 8601812
  19. A license to kill.
    Cell. 1996 Jun 14;85(6):781-4 PMID: 8681372
  20. Paclitaxel. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of cancer.
    Drugs. 1994 Nov;48(5):794-847 PMID: 7530632
  21. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.
    Cancer Res. 1993 Sep 1;53(17):3976-85 PMID: 8358726
  22. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis.
    Nature. 1996 Apr 25;380(6576):723-6 PMID: 8614469
  23. Summary of data from in vitro and phase I vinorelbine (Navelbine) studies.
    Semin Oncol. 1994 Oct;21(5 Suppl 10):14-9; discussion 19-20 PMID: 7973764
  24. Redox signaling: nitrosylation and related target interactions of nitric oxide.
    Cell. 1994 Sep 23;78(6):931-6 PMID: 7923362
  25. Expression of a multidrug-resistance gene in human tumors and tissues.
    Proc Natl Acad Sci U S A. 1987 Jan;84(1):265-9 PMID: 2432605
  26. Nitric oxide inhibits CPP32-like activity under redox regulation.
    Biochem Biophys Res Commun. 1997 Jul 18;236(2):365-9 PMID: 9240442
  27. Paclitaxel-induced apoptosis in human gastric carcinoma cell lines.
    Cancer. 1996 Jan 1;77(1):14-8 PMID: 8630921
  28. Striking similarity of the distribution patterns of the poly(ADP-ribose) polymerase and DNA polymerase beta among various mouse organs.
    Biochem Biophys Res Commun. 1990 Oct 30;172(2):377-84 PMID: 2122893
  29. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase.
    Cell. 1995 Jun 2;81(5):801-9 PMID: 7774019
  30. Apoptosis as a mechanism of cell death induced by different chemotherapeutic drugs in human leukemic T-lymphocytes.
    Biochem Pharmacol. 1996 May 17;51(10):1331-40 PMID: 8787549
  31. Apoptosis in cancer therapy: crossing the threshold.
    Cell. 1994 Aug 26;78(4):539-42 PMID: 8069905
  32. Chemotherapy-induced apoptosis in epithelial ovarian cancers.
    Obstet Gynecol. 1995 Jun;85(6):1007-10 PMID: 7770245
  33. Taxol cytotoxicity on human leukemia cell lines is a function of their susceptibility to programmed cell death.
    Cancer Chemother Pharmacol. 1995;36(5):385-92 PMID: 7634380
  34. Verapamil reversal of vincristine resistance and cross-resistance patterns of vincristine-resistant Chinese hamster ovary cells.
    Cancer Treat Rep. 1987 Apr;71(4):353-9 PMID: 2881620
Article Info
Journal
Japanese journal of cancer research : Gann
Abbr.
Jpn J Cancer Res
ISSN
0910-5050
DOI
10.1111/j.1349-7006.1998.tb00549.x
Published
1998-02-00
Pages
199-205
Language
English
Region
Japan
NLM ID
8509412
PMCID
PMC5921764
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1349-7006.1998.tb00549.x PMC Full Text
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