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题目:: Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma.
作者:: Bekri(S),Adélaïde(J),Merscher(S),Grosgeorge(J),Caroli-Bosc(F),Perucca-Lostanlen(D),Kelley(P M),Pébusque(M J),Theillet(C),Birnbaum(D),Gaudray(P)
状态:: 发布时间1998-04-22 , 更新时间 2006-11-15
期刊:: Cytogenet Cell Genet
摘要:: Amplification of loci present on band q13 of human chromosome 11 is a feature of a subset of estrogen receptor positive breast carcinomas prone to metastasis. As many as five distinct amplification units have been described on 11q13. They include particularly a genomic area encompassing the GARP gene at 11q13.5-->q14.1. We have reassessed our current knowledge of this region, located telomeric to CCND1 and EMS1, which is amplified in 7-10% of mammary tumors. The loose definition of the driving forces of these amplification events led us to map accurately the boundaries of the amplifiable region, and thus to contribute a physical and transcriptional map of a 3-Mb region of chromosome 11. Four new genes were placed on the regional map, namely CBP2, CLNS1A, UVRAG, and PAK1. We have narrowed the core of the 11q13-->q14 amplicon to a 350-kb area encompassing D11S533, mostly on its telomeric side. The map reported here represents an indispensable step toward sequencing the entire region, and thus toward uncovering gene(s) which play(s) a critical role in breast cancer progression.
语言:: eng
DOI:

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