Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells.

Nature ·Vol. 282 ·No. 5739 ·1979-12-06 ·Pages 582-6

Williams BR, Golgher RR, Brown RE, Gilbert CS, Kerr IM

Abstract

Until now the interferon-mediated 2'-5' adenine oligonucleotide inhibitors (2-5A) of cell-free protein synthesis have not been detected in intact cells. Here we report their natural occurrence in interferon-treated, EMC virus-infected mouse L cells in amounts consistent with the idea that they play a part in the inhibition of virus growth.

MeSH Terms

Adenine Nucleotides/physiology Animals Cell-Free System Encephalomyocarditis virus/growth & development Interferons/pharmacology L Cells/microbiology Mice Oligonucleotides/physiology Oligoribonucleotides/physiology RNA, Double-Stranded/pharmacology RNA, Messenger/metabolism Virus Replication/drug effects

Chemicals

Adenine Nucleotides Oligonucleotides Oligoribonucleotides RNA, Double-Stranded RNA, Messenger 2',5'-oligoadenylate Interferons

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Williams B R

Golgher R R

Brown R E

Gilbert C S

Kerr I M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/282582a0

Published

1979-12-06

Pages

582-6

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/282582a0 View journal details

Analysis Services

Natural occurrence of 2-5A in interferon-treated EMC virus-infected L cells.

Contact

WeChat Official Account