Helicases: a unifying structural theme?

Current opinion in structural biology ·Vol. 8 ·No. 1 ·1998-02-00 ·Pages 14-8

Bird LE, Subramanya HS, Wigley DB

Abstract

The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical analyses, as well as microscopy studies of hexameric helicases, a picture of a unifying structure and mechanism for all helicases is beginning to emerge.

MeSH Terms

DNA/metabolism DNA Helicases/chemistry,classification,metabolism Models, Molecular Protein Folding Structure-Activity Relationship

Chemicals

DNA DNA Helicases

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Bird L E

Sir William Dunn School of Pathology, University of Oxford, UK.

Subramanya H S

Wigley D B

Article Info

Journal

Current opinion in structural biology

Abbr.

Curr Opin Struct Biol

ISSN

0959-440X

DOI

10.1016/s0959-440x(98)80004-3

Published

1998-02-00

Pages

14-8

Language

English

Region

England

NLM ID

9107784

Subset

External Links

PubMed source DOI: 10.1016/s0959-440x(98)80004-3 View journal details

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Helicases: a unifying structural theme?

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