Abstract
The structural genes encoding the two essential components A and B of hexaprenyl diphosphate synthase, which produce the precursor of the prenyl side chain of menaquinone-6, were cloned from Micrococcus luteus B-P 26.
MeSH Terms
Alkyl and Aryl Transferases/genetics,metabolism
Amino Acid Sequence
Chromosome Mapping
Cloning, Molecular
DNA, Bacterial/analysis,genetics
Micrococcus luteus/enzymology,genetics,metabolism
Molecular Sequence Data
Plasmids
Sequence Alignment
Sequence Analysis, DNA
Sequence Homology, Amino Acid
Chemicals
DNA, Bacterial
Alkyl and Aryl Transferases
trans-pentaprenyltranstransferase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Shimizu N
Institute for Chemical Reaction Science, Tohoku University, Sendai, Japan.
Koyama T
Ogura K
References (18)
18 references, click to expand
-
Essential protein factors for polyprenyl pyrophosphate synthetases. Separation of heptaprenyl pyrophosphate synthetase into two components.
FEBS Lett. 1983 Sep 19;161(2):257-60
PMID: 6413254
-
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components.
J Biol Chem. 1982 Dec 25;257(24):14610-2
PMID: 7174655
-
Undecaprenyl diphosphate synthase from Micrococcus luteus B-P 26: essential factors for the enzymatic activity.
J Biochem. 1988 May;103(5):867-71
PMID: 3182755
-
Formation of a stable and catalytically active complex of the two essential components of hexaprenyl diphosphate synthase from Micrococcus luteus B-P 26.
Biochem Biophys Res Commun. 1989 Apr 28;160(2):448-52
PMID: 2541701
-
Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.
J Biol Chem. 1990 Aug 5;265(22):13157-64
PMID: 2198286
-
The genetics of bacterial spore germination.
Annu Rev Microbiol. 1990;44:531-53
PMID: 2252393
-
Purification of solanesyl-diphosphate synthase from Micrococcus luteus. A new class of prenyltransferase.
J Biol Chem. 1991 Dec 15;266(35):23706-13
PMID: 1748647
-
Effects of site-directed mutagenesis of the highly conserved aspartate residues in domain II of farnesyl diphosphate synthase activity.
J Biol Chem. 1992 Oct 25;267(30):21873-8
PMID: 1400496
-
Thermostable farnesyl diphosphate synthase of Bacillus stearothermophilus: molecular cloning, sequence determination, overproduction, and purification.
J Biochem. 1993 Mar;113(3):355-63
PMID: 8486607
-
Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity.
J Biol Chem. 1993 Dec 25;268(36):26983-9
PMID: 8262934
-
Yeast farnesyl-diphosphate synthase: site-directed mutagenesis of residues in highly conserved prenyltransferase domains I and II.
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3044-8
PMID: 8159703
-
Molecular cloning and nucleotide sequences of the genes for two essential proteins constituting a novel enzyme system for heptaprenyl diphosphate synthesis.
J Biol Chem. 1995 Aug 4;270(31):18396-400
PMID: 7629164
-
Identification of significant residues in the substrate binding site of Bacillus stearothermophilus farnesyl diphosphate synthase.
Biochemistry. 1996 Jul 23;35(29):9533-8
PMID: 8755734
-
Two cistrons of the gerC operon of Bacillus subtilis encode the two subunits of heptaprenyl diphosphate synthase.
J Bacteriol. 1997 Feb;179(4):1417-9
PMID: 9023232
-
Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus.
J Biol Chem. 1997 May 9;272(19):12380-3
PMID: 9139683
-
Heptaprenyl pyrophosphate synthetase from Bacillus subtilis.
J Biol Chem. 1980 May 25;255(10):4539-43
PMID: 6768722
-
Efficient enzymatic hydrolysis of polyprenyl pyrophosphates.
Biochim Biophys Acta. 1982 Sep 14;712(3):716-8
PMID: 7126635
-
Dynamic interaction between components of hexaprenyl diphosphate synthase from Micrococcus luteus BP-26.
Biochemistry. 1987 Oct 20;26(21):6840-5
PMID: 2827736