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PMID: 9510027 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development.

Mechanisms of development ·Vol. 70 ·No. 1-2 ·1998-01-00 ·Pages 91-109

Fuchs M, Wang H, Ciossek T, Chen Z, Ullrich A

Abstract

The MAM-subfamily of type II transmembrane protein tyrosine phosphatases (PTPases) currently comprises the enzymes PTPkappa, PTPmu and PCP2. In an effort to elucidate the individual physiological roles of these closely related proteins we performed a detailed analysis of their mRNA transcript distributions at different stages of mouse embryogenesis and postnatal brain development. Our in situ hybridization studies revealed distinct and complementary expression patterns of PTPkappa, PTPmu and PCP2 transcripts. Based on our results and previous reports we discuss MAM-PTPases as a new class of morphoregulatory molecules.

MeSH Terms
Amino Acid Sequence Animals Brain/embryology,growth & development DNA, Complementary/genetics Embryonic and Fetal Development/genetics Gene Expression Regulation, Developmental In Situ Hybridization Mice Molecular Sequence Data Protein Tyrosine Phosphatases/classification,genetics RNA, Messenger/genetics,metabolism Receptor Protein-Tyrosine Kinases/genetics Receptors, Growth Factor/genetics Receptors, Vascular Endothelial Growth Factor Tissue Distribution
Chemicals
DNA, Complementary RNA, Messenger Receptors, Growth Factor Receptor Protein-Tyrosine Kinases Receptors, Vascular Endothelial Growth Factor Protein Tyrosine Phosphatases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Fuchs M
Department of Molecular Biology, Max-Planck-Institut für Biochemie, Martinsried, Germany.
Wang H
Ciossek T
Chen Z
Ullrich A
Article Info
Journal
Mechanisms of development
Abbr.
Mech Dev
ISSN
0925-4773
DOI
10.1016/s0925-4773(97)00179-2
Published
1998-01-00
Pages
91-109
Language
English
Region
Ireland
NLM ID
9101218
Subset
IM
External Links
PubMed source DOI: 10.1016/s0925-4773(97)00179-2 View journal details
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