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PMID: 9495776 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Purification of an extracellular signaling molecule involved in production of aerial mycelium by Streptomyces coelicolor.

Journal of bacteriology ·Vol. 180 ·No. 5 ·1998-03-00 ·Pages 1334-7

Nodwell JR, Losick R

Abstract

We have extensively purified a factor from conditioned medium that restores aerial mycelium formation to a mutant of Streptomyces coelicolor that is defective in morphological differentiation. Response to this factor is shown to depend on the presence of the BldK oligopeptide import system. We suggest that this substance acts at the first step in a putative cascade of developmental regulatory signals.

MeSH Terms
Biological Transport Culture Media, Conditioned Genes, Bacterial Mutation Oligopeptides/chemistry,isolation & purification,metabolism Signal Transduction Streptomyces/cytology,genetics,growth & development,metabolism
Chemicals
Culture Media, Conditioned Oligopeptides
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nodwell J R
Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Losick R
References (10)
10 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.180.5.1334-1337.1998
Published
1998-03-00
Pages
1334-7
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC107025
Subset
IM
Grants
NIGMS NIH HHS · R01 GM018568 · United States
NIGMS NIH HHS · R37 GM018568 · United States
NIGMS NIH HHS · GM18568 · United States
External Links
PubMed source DOI: 10.1128/JB.180.5.1334-1337.1998 PMC Full Text View journal details
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