Abnormal carbohydrate composition of the major penetrating membrane protein of En(a-) human erythrocytes.

The Biochemical journal ·Vol. 155 ·No. 3 ·1976-06-01 ·Pages 701-3

Tanner MJ, Jenkins RE, Anstee DJ, Clamp JR

Abstract

The major penetrating membrane glycoprotein (band 3) was isolated from En(a-) and normal human erythrocytes. The two proteins differed only in carbohydrate composition. Band 3 from En(a-) erythrocytes contained greater amounts of galactose and N-acetyl-glucosamine. The loss of the sialoglycoprotein sialotetrasaccharides in the En(a-) cell is not compensated by the appearance of these units in band 3 of En(a-) erythrocytes.

MeSH Terms

Acetylglucosamine/analysis Carbohydrates/blood Cell Membrane/analysis Chromatography, Gel Erythrocytes, Abnormal/analysis Galactose/analysis Glycoproteins/analysis Humans

Chemicals

Carbohydrates Glycoproteins Acetylglucosamine Galactose

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Tanner M J

Jenkins R E

Anstee D J

Clamp J R

References (15)

15 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1550701

Published

1976-06-01

Pages

701-3

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1172895

Subset

External Links

PubMed source DOI: 10.1042/bj1550701 PMC Full Text View journal details

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Abnormal carbohydrate composition of the major penetrating membrane protein of En(a-) human erythrocytes.

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