Modulation of C3b hemolytic activity by a plasma protein distinct from C3b inactivator.

Science (New York, N.Y.) ·Vol. 193 ·No. 4257 ·1976-09-10 ·Pages 1011-3

Whaley K, Ruddy S

Abstract

A human plasma protein binds to cell-bound C3b, the major cleavage product of the third component of complement. Consequent upon this binding, C3b no longer functions in either the classical or alternative pathways. This C3b inhibitory activity is a property of a protein previously designated beta 1H on the basis of its electrophoretic mobility.

MeSH Terms

Blood Proteins/metabolism,pharmacology Complement C3/metabolism,pharmacology Complement C4/metabolism Complement System Proteins/metabolism Hemolysis/drug effects Humans Protein Binding

Chemicals

Blood Proteins Complement C3 Complement C4 Complement System Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Whaley K

Ruddy S

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.948757

Published

1976-09-10

Pages

1011-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.948757 View journal details

Analysis Services

Modulation of C3b hemolytic activity by a plasma protein distinct from C3b inactivator.

Contact

WeChat Official Account