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PMID: 9486402 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Increase of CD57+ T cells in knee joints and adjacent bone marrow of rheumatoid arthritis (RA) patients: implication for an anti-inflammatory role.

Clinical and experimental immunology ·Vol. 111 ·No. 2 ·1998-02-00 ·Pages 345-52

Arai K, Yamamura S, Seki S, Hanyu T, Takahashi HE, Abo T

Abstract

The distribution of CD57+ T and CD56+ T cells in patients with RA was examined. In control osteoarthritis patients, these cells exist as a minor population in the peripheral blood. Our data show that in patients with RA, CD57+ T cell levels are elevated in peripheral blood, knee joint fluid, knee synovial membrane and bone marrow (BM), compared with peripheral blood of controls. CD57+ T cells are especially high in knee joint fluid and joint-adjacent BM, while CD56+ T cells show no such increase. CD57+ T cells contain a major population of CD8+ cells and higher proportions of CD4-8- cells and gammadelta T cells than do CD57- T cells. CD57+ T cells in peripheral blood and joint fluid increase with the duration of disease. Erythrocyte sedimentation rate (ESR) is inversely correlated with the proportion of CD57+ T cells in the joint fluid. Although RA frequently occurs in patients with CD3+57+ cell leukaemia, and some CD57+ T cells are likely to be involved in the onset of RA, we suggest that CD57+ T cells may rather suppress inflammation of RA, and other cellular components (e.g. granulocytes) may govern the severity of the inflammation of RA. These CD57+ T cells are probably generated extrathymically in the adjacent BM or joint space.

MeSH Terms
Adult Aged Arthritis, Rheumatoid/blood,immunology,pathology Bone Marrow/immunology,pathology CD4-CD8 Ratio CD56 Antigen/immunology CD57 Antigens/immunology Female Humans Knee Joint/immunology,pathology Male Middle Aged Receptors, Antigen, T-Cell, gamma-delta/immunology Synovial Fluid/immunology T-Lymphocytes/immunology
Chemicals
CD56 Antigen CD57 Antigens Receptors, Antigen, T-Cell, gamma-delta
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Arai K
Department of Orthopaedic Surgery, Niigata University School of Medicine, Japan.
Yamamura S
Seki S
Hanyu T
Takahashi H E
Abo T
References (47)
47 references, click to expand
  1. Similarities and differences between extrathymic T cells residing in mouse liver and intestine.
    Cell Immunol. 1994 Jan;153(1):52-66 PMID: 8287493
  2. Increased percentage of CD3+, CD57+ lymphocytes in patients with rheumatoid arthritis. Correlation with duration of disease.
    Arthritis Rheum. 1993 May;36(5):608-12 PMID: 7683880
  3. Increase in the proportion of granulated CD56+ T cells in patients with malignancy.
    Clin Exp Immunol. 1994 Sep;97(3):522-7 PMID: 7521809
  4. An inhibitor of cytotoxic functions produced by CD8+CD57+ T lymphocytes from patients suffering from AIDS and immunosuppressed bone marrow recipients.
    Eur J Immunol. 1994 Nov;24(11):2882-8 PMID: 7525310
  5. Phenotypic characteristics of bone marrow cells in patients with rheumatoid arthritis.
    J Rheumatol. 1994 Sep;21(9):1608-14 PMID: 7799336
  6. Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of murine CD3+CD4-CD8- alpha beta (V alpha 4/V beta 2) T cells.
    Int Immunol. 1994 Sep;6(9):1323-31 PMID: 7819140
  7. New perspectives on rheumatoid arthritis.
    Immunol Today. 1994 Dec;15(12):553-6 PMID: 7848513
  8. Adhesion molecules on intermediate TCR cells. I. Unique expression of adhesion molecules, CD44+ L-selectin-, on intermediate TCR cells in the liver and the modulation of their adhesion by hyaluronic acid.
    Immunology. 1995 Jan;84(1):64-71 PMID: 7534265
  9. Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12.
    J Immunol. 1995 May 1;154(9):4333-40 PMID: 7722291
  10. Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation.
    J Exp Med. 1995 Sep 1;182(3):759-67 PMID: 7650483
  11. Self-reactive T cell clones in a restricted population of interleukin-2 receptor beta+ cells expressing intermediate levels of the T cell receptor in the liver and other immune organs.
    Eur J Immunol. 1995 Aug;25(8):2272-8 PMID: 7664791
  12. Relationships between intermediate TCR cells and NK1.1+ T cells in various immune organs. NK1.1+ T cells are present within a population of intermediate TCR cells.
    J Immunol. 1995 Sep 15;155(6):2972-83 PMID: 7673715
  13. Origin of CD57+ T cells which increase at tumour sites in patients with colorectal cancer.
    Clin Exp Immunol. 1995 Oct;102(1):159-66 PMID: 7554383
  14. Liver NK1.1+ CD4+ alpha beta T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis.
    J Immunol. 1996 May 1;156(9):3366-73 PMID: 8617962
  15. Interleukin-12 induces cytotoxic NK1+ alpha beta T cells in the lungs of euthymic and athymic mice.
    Immunology. 1996 May;88(1):82-9 PMID: 8707355
  16. c-kit+ stem cells and thymocyte precursors in the livers of adult mice.
    J Exp Med. 1996 Aug 1;184(2):687-93 PMID: 8760822
  17. Cytotoxic gammadelta or alphabeta T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2.
    J Immunol. 1996 Nov 1;157(9):3886-92 PMID: 8892619
  18. Simultaneous activation of granulocytes and extrathymic T cells in number and function by excessive administration of nonsteroidal anti-inflammatory drugs.
    Cell Immunol. 1996 Nov 1;173(2):303-11 PMID: 8912891
  19. Extrathymic differentiation of resident T cells in the joints of mice with collagen-induced arthritis.
    J Immunol. 1996 Dec 1;157(11):5170-7 PMID: 8943429
  20. Absolute dependence of T cell receptor(hi) cell generation and relative dependence of T cell receptor(int) cell generation on the thymus.
    Eur J Immunol. 1997 Feb;27(2):361-7 PMID: 9045905
  21. Mouse liver T cells: their change with aging and in comparison with peripheral T cells.
    Hepatology. 1997 Aug;26(2):301-9 PMID: 9252138
  22. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).
    J Immunol. 1981 Sep;127(3):1024-9 PMID: 6790607
  23. Characterization of HNK-1+ (Leu-7) human lymphocytes. I. Two distinct phenotypes of human NK cells with different cytotoxic capability.
    J Immunol. 1982 Oct;129(4):1752-7 PMID: 6980948
  24. Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.
    Nature. 1984 Sep 13-19;311(5982):153-5 PMID: 6206400
  25. Morphologic and phenotypic features of the subpopulation of Leu-2+ cells that suppresses B cell differentiation.
    J Immunol. 1984 Nov;133(5):2461-8 PMID: 6237150
  26. HNK-1+ (Leu-7) and other lymphocyte subsets in long-term survivors with renal allotransplants.
    Transplantation. 1985 Jan;39(1):25-9 PMID: 3880961
  27. Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes.
    J Clin Invest. 1985 Mar;75(3):932-43 PMID: 3884668
  28. Cytomegalovirus infection in cardiac transplant recipients associated with chronic T cell subset ratio inversion with expansion of a Leu-7+ TS-C+ subset.
    Clin Exp Immunol. 1985 Dec;62(3):515-24 PMID: 3002689
  29. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.
    J Immunol. 1986 Jun 15;136(12):4480-6 PMID: 3086432
  30. A subset of natural killer cells in peripheral blood displays a mature T cell phenotype.
    J Exp Med. 1986 Jul 1;164(1):351-6 PMID: 3088199
  31. Persistence of T8+/HNK-1+ suppressor lymphocytes in the blood of long-term surviving patients after allogeneic bone marrow transplantation.
    J Immunol. 1986 Oct 1;137(7):2180-9 PMID: 2944951
  32. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
    Arthritis Rheum. 1988 Mar;31(3):315-24 PMID: 3358796
  33. In vitro inhibition of normal human hematopoiesis by marrow CD3+, CD8+, HLA-DR+, HNK1+ lymphocytes.
    Blood. 1988 Nov;72(5):1616-21 PMID: 2972326
  34. The presence of a myeloid cell population showing strong reactivity with monoclonal antibody directed to difucosyl type 2 chain in epiphyseal bone marrow adjacent to joints affected with rheumatoid arthritis (RA) and its absence in the corresponding normal and non-RA bone marrow.
    J Rheumatol. 1988 Nov;15(11):1609-15 PMID: 3236296
  35. Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule.
    J Exp Med. 1989 Jun 1;169(6):2233-8 PMID: 2471777
  36. Cell-mediated suppression of HIV-specific cytotoxic T lymphocytes.
    J Immunol. 1989 Oct 1;143(7):2193-201 PMID: 2476500
  37. Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice.
    J Exp Med. 1990 Jul 1;172(1):7-12 PMID: 2141631
  38. Increased frequencies of the CD29 and CD57 markers and decreased frequency of CD45RA within CD4+ and CD8+ subsets after allogeneic bone marrow transplantation in man.
    Scand J Immunol. 1991 May;33(5):499-504 PMID: 1709516
  39. The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria.
    J Exp Med. 1991 Aug 1;174(2):417-24 PMID: 1677392
  40. Clonal diseases of large granular lymphocytes.
    Blood. 1993 Jul 1;82(1):1-14 PMID: 8324214
  41. Unusual alpha beta-T cells expanded in autoimmune lpr mice are probably a counterpart of normal T cells in the liver.
    J Immunol. 1991 Aug 15;147(4):1214-21 PMID: 1831220
  42. CD4+CD7-CD57+ T cells: a new T-lymphocyte subset expanded during human immunodeficiency virus infection.
    Blood. 1992 Apr 1;79(7):1746-53 PMID: 1373086
  43. Rheumatoid synovium is enriched in CD45RBdim mature memory T cells that are potent helpers for B cell differentiation.
    Arthritis Rheum. 1992 Dec;35(12):1455-65 PMID: 1472123
  44. Pathogenesis of rheumatoid arthritis.
    Lancet. 1993 Jan 30;341(8840):283-6 PMID: 8093927
  45. Ontogeny and development of extrathymic T cells in mouse liver.
    Immunology. 1992 Dec;77(4):556-63 PMID: 1493929
  46. Extrathymic development of V alpha 14-positive T cells.
    J Exp Med. 1993 May 1;177(5):1399-408 PMID: 8386744
  47. Extrathymic pathways of T-cell differentiation in the liver and other organs.
    Int Rev Immunol. 1994;11(1):61-102 PMID: 8057045
Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
DOI
10.1046/j.1365-2249.1998.00511.x
Published
1998-02-00
Pages
345-52
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1904913
Subset
IM
External Links
PubMed source DOI: 10.1046/j.1365-2249.1998.00511.x PMC Full Text View journal details
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