Phosphatases and tumorigenesis.

Current opinion in oncology ·Vol. 10 ·No. 1 ·1998-01-00 ·Pages 88-91

Parsons R

Abstract

Phosphatases are regulatory enzymes that antagonize the action of kinases within the cell. An understanding of the contribution of kinases to cancer has emerged during the past two decades; however, our understanding of phosphatases in cancer has lagged behind. Currently, three phosphatases have been implicated in the etiology of tumors: protein phosphatase 2A, CDC25A/B, and PTEN (or MMAC1). Protein phosphatase 2A and PTEN behave as tumor suppressors, whereas CDC25A and -B act as oncogenes.

MeSH Terms

Animals Cell Cycle Proteins/genetics,metabolism Female GTP-Binding Proteins/genetics,metabolism Gene Expression Regulation, Enzymologic Genes, Tumor Suppressor/genetics Humans Male Neoplasms/enzymology,etiology Oncogenes/genetics PTEN Phosphohydrolase Phosphoprotein Phosphatases/genetics,metabolism Phosphoric Monoester Hydrolases Protein Phosphatase 2 Protein Tyrosine Phosphatases/genetics,metabolism Tumor Suppressor Proteins cdc25 Phosphatases

Chemicals

Cell Cycle Proteins Tumor Suppressor Proteins Phosphoprotein Phosphatases Protein Phosphatase 2 Phosphoric Monoester Hydrolases Protein Tyrosine Phosphatases cdc25 Phosphatases PTEN Phosphohydrolase PTEN protein, human GTP-Binding Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Parsons R

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Article Info

Journal

Current opinion in oncology

Abbr.

Curr Opin Oncol

ISSN

1040-8746

DOI

10.1097/00001622-199801000-00014

Published

1998-01-00

Pages

88-91

Language

English

Region

United States

NLM ID

9007265

Subset

External Links

PubMed source DOI: 10.1097/00001622-199801000-00014 View journal details

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