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PMID: 9465042 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Is the molten globule a third phase of proteins?

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 4 ·1998-02-17 ·Pages 1490-4

Pande VS, Rokhsar DS

Abstract

The equilibrium properties of proteins are studied by Monte Carlo simulation of two simplified models of protein-like heteropolymers. These models emphasize the polymeric entropy of the fluctuating polypeptide chain. Our calculations suggest a generic phase diagram that contains a thermodynamically distinct "molten globule" state in addition to a rigid native state and a nontrivial unfolded state. The roles of side-chain packing and loop entropy are discussed.

MeSH Terms
Chemical Phenomena Chemistry, Physical Entropy Hydrogen Bonding Models, Biological Monte Carlo Method Polymers Protein Conformation Protein Folding Proteins/chemistry Staphylococcal Protein A Temperature Thermodynamics
Chemicals
Polymers Proteins Staphylococcal Protein A
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Pande V S
Department of Physics, University of California at Berkeley, Berkeley, CA 94720, USA.
Rokhsar D S
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.4.1490
Published
1998-02-17
Pages
1490-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC19058
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.95.4.1490 PMC Full Text View journal details
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