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PMID: 9441674 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse.

Developmental biology ·Vol. 192 ·No. 2 ·1997-12-15 ·Pages 364-74

Friedrich GA, Hildebrand JD, Soriano P

Abstract

The sec8 gene, isolated in a gene trap screen in embryonic stem cells, is required for paraxial mesoderm formation in the mouse. Homozygous sec8 mutant embryos initiate gastrulation but are unable to progress beyond the primitive streak stage and die shortly afterward. The genomic locus and cDNA of the sec8 gene have been cloned. An open reading frame in the cDNA encodes a 971-amino-acid leucine-rich protein, similar to rat rSec8. A description of the mutant phenotype and the cloning of the gene is presented here and the results are considered in light of the possibility that the Sec8 protein is involved in secretion.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Carrier Proteins Cloning, Molecular DNA, Complementary/genetics Embryonic and Fetal Development/physiology Exocytosis/physiology Gastrula/physiology Gene Expression Regulation, Developmental Genes Membrane Proteins Mesoderm/physiology Mice Mice, Mutant Strains Molecular Sequence Data Proteins/genetics,physiology Rats Saccharomyces cerevisiae/physiology Saccharomyces cerevisiae Proteins Species Specificity Vesicular Transport Proteins
Chemicals
Carrier Proteins DNA, Complementary Exoc4 protein, rat Membrane Proteins Proteins SEC8 protein, S cerevisiae Saccharomyces cerevisiae Proteins Sec8l1 protein, mouse Vesicular Transport Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Friedrich G A
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
Hildebrand J D
Soriano P
Article Info
Journal
Developmental biology
Abbr.
Dev Biol
ISSN
0012-1606
DOI
10.1006/dbio.1997.8727
Published
1997-12-15
Pages
364-74
Language
English
Region
United States
NLM ID
0372762
Subset
IM
External Links
PubMed source DOI: 10.1006/dbio.1997.8727 View journal details
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