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题目:: Recognition of rheumatoid arthritis synovial antigen by CD4+,CD8- T cell clones established from rheumatoid arthritis joints.
作者:: Toyosaki(T),Tsuruta(Y),Yoshioka(T),Takemoto(H),Suzuki(R),Tomita(T),Ochi(T)
状态:: 发布时间1998-01-29 , 更新时间 2011-11-17
期刊:: Arthritis Rheum
摘要:: To investigate the rheumatoid arthritis (RA)-specific autoantigen(s) recognized by CD4+ T cells in patients with RA.,CD4+,CD45RO+ T cell clones were established from the joints of RA patients, and were examined for their proliferative response to synovial cells.,Eight of 146 T cell clones responded to RA synovial cells in a DR-restricted manner. These T cell clones recognized solubilized antigens extracted from RA synovial cells in the presence of DR-matched antigen-presenting cells, but did not respond to those extracted from non-RA synovial cells. The antigens had a molecular weight of 50/25 kd. Five of the 8 T cell clones used T cell receptor BV6, and the remaining clones used BV12.2.,The antigens recognized by joint-infiltrating CD4+ T cells are present exclusively in RA synovial cells. The expression of these antigens by synovial cells may trigger the autoreactivity of T cells in RA joints.
语言:: eng
DOI:: 10.1002/1529-0131(199801)41:1<92::AID-ART12>3.0.CO;2-2

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