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PMID: 9407001 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.

DNA and cell biology ·Vol. 16 ·No. 11 ·1997-11-00 ·Pages 1289-98

Kiriakidou M, Driscoll DA, Lopez-Guisa JM, Strauss JF

Abstract

Murine Daxx, a protein that binds to Fas and enhances Fas-mediated apoptosis through a signal transduction pathway involving the Jun amino-terminal kinase, was recently described. Here we report the cloning of human and monkey Daxx cDNAs, the widespread expression of Daxx mRNA in human tissues, and the mapping of the human Daxx gene to 6p21.3 in the major histocompatibility complex (MHC) region. The location of the Daxx gene, which is implicated in the pathway for deletion of autoreactive lymphocytes, in the MHC region may shed light on the genetic basis of autoimmune diseases.

MeSH Terms

Adaptor Proteins, Signal Transducing Adult Amino Acid Sequence Animals Apoptosis Base Sequence COS Cells Carrier Proteins/genetics Chromosome Mapping Chromosomes, Human, Pair 6 Cloning, Molecular Co-Repressor Proteins DNA/chemistry DNA, Complementary/chemistry Gene Expression Haplorhini HeLa Cells Humans Intracellular Signaling Peptides and Proteins Major Histocompatibility Complex/genetics Mice Models, Genetic Molecular Chaperones Molecular Sequence Data Nuclear Proteins Sequence Alignment Signal Transduction fas Receptor/metabolism

Chemicals

Adaptor Proteins, Signal Transducing Carrier Proteins Co-Repressor Proteins DAXX protein, human DNA, Complementary Daxx protein, mouse Intracellular Signaling Peptides and Proteins Molecular Chaperones Nuclear Proteins fas Receptor DNA

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kiriakidou M

Center for Research on Reproduction and Women's Health and Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104, USA.

Driscoll D A

Lopez-Guisa J M

Strauss J F

Article Info

Journal

DNA and cell biology

Abbr.

DNA Cell Biol

ISSN

1044-5498

DOI

10.1089/dna.1997.16.1289

Published

1997-11-00

Pages

1289-98

Language

English

Region

United States

NLM ID

9004522

Subset

Grants

NICHD NIH HHS · HD 34612 · United States

NICHD NIH HHS · HD34449 · United States

Databases

GENBANK

AF050179

External Links

PubMed source DOI: 10.1089/dna.1997.16.1289 View journal details

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Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region.

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