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PMID: 9393812 Published · ppublish English Journal Article

Passive protection by polyclonal antibodies against Bacillus anthracis infection in guinea pigs.

Infection and immunity ·Vol. 65 ·No. 12 ·1997-12-00 ·Pages 5171-5

Little SF, Ivins BE, Fellows PF, Friedlander AM

Abstract

The protective effects of polyclonal antisera produced by injecting guinea pigs with protective antigen (PA), the chemical anthrax vaccine AVA, or Sterne spore vaccine, as well as those of toxin-neutralizing monoclonal antibodies (MAbs) produced against PA, lethal factor, and edema factor, were examined in animals infected with Bacillus anthracis spores. Only the anti-PA polyclonal serum significantly protected the guinea pigs from death, with 67% of infected animals surviving. Although none of the MAbs was protective, one PA MAb caused a significant delay in time to death. Our findings demonstrate that antibodies produced against only PA can provide passive protection against anthrax infection in guinea pigs.

MeSH Terms
Animals Anthrax/prevention & control Antibodies, Bacterial/administration & dosage,immunology Antibodies, Monoclonal/administration & dosage,immunology Bacillus anthracis/immunology Bacterial Vaccines/administration & dosage,immunology Guinea Pigs
Chemicals
Antibodies, Bacterial Antibodies, Monoclonal Bacterial Vaccines
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Little S F
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011, USA.
Ivins B E
Fellows P F
Friedlander A M
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.65.12.5171-5175.1997
Published
1997-12-00
Pages
5171-5
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC175745
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.65.12.5171-5175.1997 PMC Full Text View journal details
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