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PMID: 9389475 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.

Nature ·Vol. 390 ·No. 6658 ·1997-11-27 ·Pages 364-70

Klenk HP, Clayton RA, Tomb JF, White O, Nelson KE, Ketchum KA, Dodson RJ, Gwinn M, Hickey EK, Peterson JD, Richardson DL, Kerlavage AR, Graham DE, Kyrpides NC, Fleischmann RD, Quackenbush J, Lee NH, Sutton GG, Gill S, Kirkness EF, Dougherty BA, McKenney K, Adams MD, Loftus B, Peterson S, Reich CI, McNeil LK, Badger JH, Glodek A, Zhou L, Overbeek R, Gocayne JD, Weidman JF, McDonald L, Utterback T, Cotton MD, Spriggs T, Artiach P, Kaine BP, Sykes SM, Sadow PW, D'Andrea KP, Bowman C, Fujii C, Garland SA, Mason TM, Olsen GJ, Fraser CM, Smith HO, Woese CR, Venter JC

Abstract

Archaeoglobus fulgidus is the first sulphur-metabolizing organism to have its genome sequence determined. Its genome of 2,178,400 base pairs contains 2,436 open reading frames (ORFs). The information processing systems and the biosynthetic pathways for essential components (nucleotides, amino acids and cofactors) have extensive correlation with their counterparts in the archaeon Methanococcus jannaschii. The genomes of these two Archaea indicate dramatic differences in the way these organisms sense their environment, perform regulatory and transport functions, and gain energy. In contrast to M. jannaschii, A. fulgidus has fewer restriction-modification systems, and none of its genes appears to contain inteins. A quarter (651 ORFs) of the A. fulgidus genome encodes functionally uncharacterized yet conserved proteins, two-thirds of which are shared with M. jannaschii (428 ORFs). Another quarter of the genome encodes new proteins indicating substantial archaeal gene diversity.

MeSH Terms

Archaeoglobus fulgidus/genetics,metabolism,physiology Base Sequence Cell Division DNA, Bacterial/genetics Energy Metabolism Gene Expression Regulation, Bacterial Genes, Archaeal Genome Molecular Sequence Data Protein Biosynthesis Transcription, Genetic

Chemicals

DNA, Bacterial

Authors & Affiliations

51 authors, click to expand affiliations / ORCID

Klenk H P

Institute for Genomic Research, Rockville, Maryland 20850, USA.

Clayton R A

Tomb J F

White O

Nelson K E

Ketchum K A

Dodson R J

Gwinn M

Hickey E K

Peterson J D

Richardson D L

Kerlavage A R

Graham D E

Kyrpides N C

Fleischmann R D

Quackenbush J

Lee N H

Sutton G G

Gill S

Kirkness E F

Dougherty B A

McKenney K

Adams M D

Loftus B

Peterson S

Reich C I

McNeil L K

Badger J H

Glodek A

Zhou L

Overbeek R

Gocayne J D

Weidman J F

McDonald L

Utterback T

Cotton M D

Spriggs T

Artiach P

Kaine B P

Sykes S M

Sadow P W

D'Andrea K P

Bowman C

Fujii C

Garland S A

Mason T M

Olsen G J

Fraser C M

Smith H O

Woese C R

Venter J C

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/37052

Published

1997-11-27

Pages

364-70

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

AE000943, AE000944, AE000945, AE000946, AE000947, AE000948, AE000949, AE000950, AE000951, AE000952, AE000953, AE000954, AE000955, AE000956, AE000957, AE000958, AE000959, AE000960, AE000961, AE000962, AE000963, AE000964, AE000965, AE000966, AE000967, AE000968, AE000969

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1038/37052 View journal details

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The complete genome sequence of the hyperthermophilic, sulphate-reducing archaeon Archaeoglobus fulgidus.

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