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PMID: 938021 Published · ppublish English Comparative Study Journal Article

Comparison of in vitro antimicrobial activity of cefamandole and cefazolin with cephalothin against over 8,000 clinical bacterial isolates.

Antimicrobial agents and chemotherapy ·Vol. 9 ·No. 6 ·1976-06-00 ·Pages 1066-9

Jones RN, Fuchs PC

Abstract

Antimicrobial susceptibility to cefamandole versus cephalothin and cefazolin versus cephalothin was compared by the broth microdilution method against 3,000 and 5,895 clinical bacterial isolates, respectively. Cefamandole and, to a lesser degree, cefazolin showed greater activity than cephalothin against Enterobacteriaceae, but the three drugs were comparable against gram-positive cocci.

MeSH Terms
Bacteria/drug effects Cefazolin/pharmacology Cephalosporins/pharmacology Cephalothin/pharmacology Drug Combinations Drug Resistance, Microbial Enterobacteriaceae/drug effects Mandelic Acids
Chemicals
Cephalosporins Drug Combinations Mandelic Acids Cefazolin Cephalothin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jones R N
Fuchs P C
References (7)
7 references, click to expand
  1. Cefamandole, a cephalosporin antibiotic with an unusually wide spectrum of activity.
    Antimicrob Agents Chemother. 1974 Aug;6(2):177-82 PMID: 15828189
  2. In vitro activity of cefazolin against recent clinical bacterial isolates.
    J Infect Dis. 1973 Oct;128:Suppl:S320-6 PMID: 4200651
  3. In vitro studies with cefazolin.
    Antimicrob Agents Chemother. 1974 Dec;6(6):856-61 PMID: 4451358
  4. Evaluation of cefazolin, a new cephalosporin antibiotic.
    Antimicrob Agents Chemother. 1973 Apr;3(4):488-97 PMID: 4790605
  5. Clinical and in vitro evaluation of cefazolin, a new cephalosporin antibiotic.
    Antimicrob Agents Chemother. 1973 Feb;3(2):168-74 PMID: 4790584
  6. Comparison of cefazolin, a new cephalosporin antibiotic, with cephalothin.
    Antimicrob Agents Chemother. 1972 Oct;2(4):329-30 PMID: 4670505
  7. Biological properties of three 3-heterocyclic-thiomethyl cephalosporin antibiotics.
    Antimicrob Agents Chemother. 1972 Mar;1(3):221-34 PMID: 5045468
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
Published
1976-06-00
Pages
1066-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC429673
Subset
IM
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