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PMID: 9375022 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

E2F transcription factor action, regulation and possible role in human cancer.

Cell proliferation ·Vol. 30 ·No. 3-4 ·1997-00-00 ·Pages 97-105

Sladek TL

Abstract

E2F transcription factors regulate expression of a panel of cellular genes that control cellular DNA synthesis and proliferation, either by activating or repressing their transcription, largely in a cell cycle-dependent manner. The ability of E2F proteins to regulate expression of these target genes is, in turn, regulated by other cellular proteins that are important for normal control of cell cycle progression. Together, E2F proteins, their target genes, and the proteins that regulate E2F activity comprise a genetic pathway that is probably the most, frequently altered pathway in human cancer. This review examines this genetic pathway and focuses on the role of E2F proteins in its function. Specifically, the target genes regulated by E2F, the likely mechanisms by which activation and repression of target gene transcription is achieved, and the regulation of E2F activity by other proteins in the cell, are discussed.

MeSH Terms
Carrier Proteins Cell Cycle Proteins/metabolism Cell Division/genetics DNA-Binding Proteins E2F Transcription Factors Gene Expression Regulation, Neoplastic Humans Neoplasms/etiology Retinoblastoma-Binding Protein 1 Transcription Factor DP1 Transcription Factors/metabolism Transcription, Genetic
Chemicals
Carrier Proteins Cell Cycle Proteins DNA-Binding Proteins E2F Transcription Factors Retinoblastoma-Binding Protein 1 Transcription Factor DP1 Transcription Factors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Sladek T L
Department of Microbiology and Immunology, Finch University of Health Sciences, Chicago Medical School, Illinois 60064-3095, USA. sladekt@mis.finchcms.edu
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Article Info
Journal
Cell proliferation
Abbr.
Cell Prolif
ISSN
0960-7722
Email
sladekt@mis.finchcms.edu
Published
1997-00-00
Pages
97-105
Language
English
Region
England
NLM ID
9105195
PMCID
PMC6495789
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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