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题目:: Spontaneous polyploidization results in apoptosis in a Meth-A tumor cell line.
作者:: Fujikawa-Yamamoto(K),Zong(Z P),Murakami(M),Odashima(S),Ikeda(T),Yoshitake(Y)
状态:: 发布时间1998-02-10 , 更新时间 2013-11-21
期刊:: Cell Struct Funct
摘要:: Cultured Meth-A cells always include a small fraction of large cells, which had a DNA content above 4c (polyploid cells). The process from the formation to the disintegration of polyploid Meth-A cells was measured by means of time-lapse videography. Polyploid Meth-A cells arose spontaneously from normal cells (polyploidization), then died by apoptosis. The fraction of polyploid cells gradually increased in seven day-exponential cultures with a low concentration of demecolcine, which is a specific inhibitor of cell division. The results revealed that the polyploid Meth-A cells are generated from normal cells by failing cell division and that they die by apoptosis.
语言:: eng
DOI:

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