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PMID: 9363890 Published · ppublish English Journal Article

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

Nature ·Vol. 390 ·No. 6655 ·1997-11-06 ·Pages 45-51

Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI

Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

MeSH Terms

Aging/genetics,pathology Amino Acid Sequence Animals Arteriosclerosis/genetics,pathology Atrophy Calcinosis/genetics,pathology Cloning, Molecular Emphysema/genetics Female Genitalia/pathology Humans Male Membrane Proteins/genetics,physiology Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Transgenic Molecular Sequence Data Mutagenesis, Insertional Osteoporosis/genetics,pathology Phenotype Pituitary Gland/pathology Sequence Homology, Amino Acid Skin/pathology Syndrome Thymus Gland/pathology

Chemicals

Membrane Proteins

Authors & Affiliations

16 authors, click to expand affiliations / ORCID

Kuro-o M

Division of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan. kuroo@ncnaxp.ncnp.go.jp

Matsumura Y

Aizawa H

Kawaguchi H

Suga T

Utsugi T

Ohyama Y

Kurabayashi M

Kaname T

Kume E

Iwasaki H

Iida A

Shiraki-Iida T

Nishikawa S

Nagai R

Nabeshima Y I

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/36285

kuroo@ncnaxp.ncnp.go.jp

Published

1997-11-06

Pages

45-51

Language

English

Region

England

NLM ID

0410462

Subset

Databases

GENBANK

AB005141, AB005142, AB010088, AB010089, AB010090, AB010091

Corrections

CommentIn

PMID: 9363884

External Links

PubMed source DOI: 10.1038/36285 View journal details

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

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