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PMID: 9354792 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

A novel gene involved in zinc transport is deficient in the lethal milk mouse.

Nature genetics ·Vol. 17 ·No. 3 ·1997-11-00 ·Pages 292-7

Huang L, Gitschier J

Abstract

We have identified the gene responsible for the inherited zinc deficiency in the lethal milk (lm) mouse. The gene, here designated Znt4, encodes a 430-amino-acid protein that is homologous to two proteins, ZnT2 and ZnT3, responsible for sequestration of zinc into endosomal/lysosomal compartments and synaptic vesicles, respectively. We show that the Znt4 gene confers zinc resistance to a zinc-sensitive yeast strain and that it is abundantly expressed in the mammary epithelia and brain. The lethal milk mutant has a nonsense mutation at arginine codon 297 in the Znt4 gene.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Blood Proteins/genetics Carrier Proteins/genetics,metabolism Cation Transport Proteins Chromosome Mapping Cloning, Molecular Cytoskeletal Proteins Female Humans Mammary Glands, Animal/metabolism Membrane Proteins Mice Mice, Inbred C57BL Mice, Mutant Strains/genetics Molecular Sequence Data Mutation Recombinant Proteins/genetics,metabolism Tissue Distribution Yeasts/genetics Zinc/deficiency,metabolism
Chemicals
Blood Proteins Carrier Proteins Cation Transport Proteins Cytoskeletal Proteins Membrane Proteins Recombinant Proteins SLC30A4 protein, human Slc30a4 protein, mouse erythrocyte membrane band 4.2 protein Zinc
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Huang L
Howard Hughes Medical Institute, University of California, San Francisco 94143, USA.
Gitschier J
Article Info
Journal
Nature genetics
Abbr.
Nat Genet
ISSN
1061-4036
DOI
10.1038/ng1197-292
Published
1997-11-00
Pages
292-7
Language
English
Region
United States
NLM ID
9216904
Subset
IM
Databases
GENBANK
AF003747, AF004097, AF004098, AF004099, AF004100, AF025409
External Links
PubMed source DOI: 10.1038/ng1197-292 View journal details
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