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PMID: 9351176 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.

Trends in microbiology ·Vol. 5 ·No. 10 ·1997-10-00 ·Pages 399-405

Speck SH, Chatila T, Flemington E

Abstract

The switch from latent infection to virus replication in Epstein-Barr virus (EBV)-infected B cells is initiated by expression of the viral BZLF1 gene. Recent studies have identified the key cellular transcription factors involved in regulating this switch in viral programs and the signal transduction pathways to which they respond. Understanding this switch may facilitate development of strategies to interfere with EBV infection.

MeSH Terms

Animals DNA-Binding Proteins/genetics Gene Expression Regulation, Viral Genes, Viral Herpesvirus 4, Human/genetics,growth & development Humans Trans-Activators/genetics Viral Proteins Viral Structural Proteins/genetics Virus Activation

Chemicals

BZLF1 protein, Herpesvirus 4, Human DNA-Binding Proteins Trans-Activators Viral Proteins Viral Structural Proteins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Speck S H

Dept of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA. speck@pathology.wustl.edu

Chatila T

Flemington E

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/S0966-842X(97)01129-3

speck@pathology.wustl.edu

Published

1997-10-00

Pages

399-405

Language

English

Region

England

NLM ID

9310916

Subset

Grants

NIAID NIH HHS · AI30550 · United States

NCI NIH HHS · CA52004 · United States

NIGMS NIH HHS · GM48045 · United States

External Links

PubMed source DOI: 10.1016/S0966-842X(97)01129-3 View journal details

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Reactivation of Epstein-Barr virus: regulation and function of the BZLF1 gene.

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