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PMID: 9345902 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4.

Cytogenetics and cell genetics ·Vol. 78 ·No. 1 ·1997-00-00 ·Pages 31-5

Lamartine J, Seri M, Cinti R, Heitzmann F, Creaven M, Radomski N, Jost E, Lenoir GM, Romeo G, Sylla BS

Abstract

We have identified a novel human gene with strong homology to the mouse Pa2g4 cell cycle gene. This novel gene (called PA2G4) belongs to a gene family with members in several chromosome regions: 3q24-q25, 6q22, 9q21, 12q13, 18q12, 20p12 and Xq25. A composite cDNA of 1697 nucleotides was isolated. The sequence of this cDNA predicts a protein of 394 amino acids. The deduced amino acid sequence of this human protein shows very strong homology to the mouse protein p38-2G4. The cDNA analyzed probably corresponds to a functional copy found at 12q13.

MeSH Terms
Animals Base Sequence Blotting, Northern Cell Cycle/genetics Chromosome Banding Chromosome Mapping Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 20 Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 6 Chromosomes, Human, Pair 9 Cloning, Molecular DNA, Complementary/isolation & purification DNA-Binding Proteins Female Humans Intestines/chemistry Leukocytes/chemistry Male Mice Molecular Sequence Data Nuclear Proteins/genetics Ovary/chemistry Prostate/chemistry Pseudogenes RNA, Messenger/analysis RNA-Binding Proteins Sequence Homology, Amino Acid Spleen/chemistry Testis/chemistry X Chromosome
Chemicals
DNA, Complementary DNA-Binding Proteins Nuclear Proteins Pa2g4 protein, mouse RNA, Messenger RNA-Binding Proteins
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Lamartine J
International Agency for Research on Cancer, Lyon, France.
Seri M
Cinti R
Heitzmann F
Creaven M
Radomski N
Jost E
Lenoir G M
Romeo G
Sylla B S
Article Info
Journal
Cytogenetics and cell genetics
Abbr.
Cytogenet Cell Genet
ISSN
0301-0171
Published
1997-00-00
Pages
31-5
Language
English
Region
Switzerland
NLM ID
0367735
Subset
IM
Databases
GENBANK
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