Quinolone susceptibility of norA-disrupted Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 41 ·No. 10 ·1997-10-00 ·Pages 2308-9

Yamada H, Kurose-Hamada S, Fukuda Y, Mitsuyama J, Takahata M, Minami S, Watanabe Y, Narita H

Abstract

The MIC of norfloxacin for the norA-disrupted mutant termed RDN1, obtained from quinolone-susceptible Staphylococcus aureus RN4220, was eightfold lower than that for RN4220. The increase in susceptibility was related to an increase of drug accumulation by RDN1. These results indicate that NorA plays an important role in the susceptibility of quinolone-susceptible S. aureus to selected quinolones.

MeSH Terms

4-Quinolones Anti-Infective Agents/chemistry,pharmacology Blotting, Southern Drug Resistance, Microbial Genes, Bacterial/genetics,physiology Microbial Sensitivity Tests Mutation Staphylococcus aureus/drug effects,genetics

Chemicals

4-Quinolones Anti-Infective Agents

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Yamada H

Research Laboratories, Toyama Chemical Co. Ltd., Toyama City, Japan.

Kurose-Hamada S

Fukuda Y

Mitsuyama J

Takahata M

Minami S

Watanabe Y

Narita H

References (13)

13 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.41.10.2308

Published

1997-10-00

Pages

2308-9

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC164117

Subset

External Links

PubMed source DOI: 10.1128/AAC.41.10.2308 PMC Full Text View journal details

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Quinolone susceptibility of norA-disrupted Staphylococcus aureus.

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