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PMID: 9332905 Published · ppublish English Clinical Trial Comparative Study Journal Article

Interleukin-6-(IL-6) plasma levels in depression and schizophrenia: comparison between the acute state and after remission.

European archives of psychiatry and clinical neuroscience ·Vol. 247 ·No. 4 ·1997-00-00 ·Pages 228-33

Frommberger UH, Bauer J, Haselbauer P, Fräulin A, Riemann D, Berger M

Abstract

The concentration of cytokines such as Interleukin-6 (IL-6) has been reported to be elevated in depressed and schizophrenic patients and, in healthy persons, upon stress. Interleukin-6 plasma levels were determined in depressed (n = 12) and schizophrenic (n = 32) patients during the acute state of illness and after remission at approximately 8 weeks after admission and were compared with healthy controls (n = 12). Patients were diagnosed according to DSM-III-R by the Structured Clinical Interview (SCID). Severity of illness was assessed for depression by the Montgomery Asberg Depression Rating Scale (MADRS) and for schizophrenia by the Brief Psychiatric Rating Scale (BPRS). Interleukin-6 plasma concentrations were elevated during the acute state either of depression or of schizophrenia if compared to controls. After remission, IL-6 concentrations in depressed and in schizophrenic patients had decreased and did not differ significantly from controls. We hypothesize that the elevated IL-6 levels during the acute state of depression or schizophrenia may reflect an unspecific stress response.

MeSH Terms
Acute Disease Adult Antidepressive Agents/therapeutic use Antipsychotic Agents/therapeutic use Depressive Disorder/blood,drug therapy,psychology Female Humans Interleukin-6/blood Male Middle Aged Psychiatric Status Rating Scales Schizophrenia/blood,drug therapy Schizophrenic Psychology
Chemicals
Antidepressive Agents Antipsychotic Agents Interleukin-6
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Frommberger U H
Department of Psychiatry, University of Freiburg, Germany.
Bauer J
Haselbauer P
Fräulin A
Riemann D
Berger M
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Article Info
Journal
European archives of psychiatry and clinical neuroscience
Abbr.
Eur Arch Psychiatry Clin Neurosci
ISSN
0940-1334
DOI
10.1007/BF02900219
Published
1997-00-00
Pages
228-33
Language
English
Region
Germany
NLM ID
9103030
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02900219 View journal details
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