Helicase structures: a new twist on DNA unwinding.

Structure (London, England : 1993) ·Vol. 5 ·No. 9 ·1997-09-15 ·Pages 1129-34

Marians KJ

Abstract

The crystal structures of two members of the SF1 family of helicases, Rep and PcrA, and one member of the SF2 family of helicases, the HCV RNA helicase, have recently been solved. These structures illuminate the roles of the conserved helicase motifs in catalytic function and offer clues as to how these proteins can translocate along DNA.

MeSH Terms

Amino Acid Sequence Bacterial Proteins/chemistry Catalysis Conserved Sequence Crystallography, X-Ray DNA/metabolism DNA Helicases/chemistry,metabolism DNA-Binding Proteins Models, Molecular Molecular Sequence Data Protein Conformation Protein Structure, Secondary Trans-Activators/chemistry

Chemicals

Bacterial Proteins DNA-Binding Proteins Trans-Activators pcrA protein, Bacteria replication initiator protein DNA DNA Helicases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Marians K J

Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. k-marians@ski.mskcc.org

Article Info

Journal

Structure (London, England : 1993)

Abbr.

Structure

ISSN

0969-2126

DOI

10.1016/s0969-2126(97)00263-3

k-marians@ski.mskcc.org

Published

1997-09-15

Pages

1129-34

Language

English

Region

United States

NLM ID

101087697

Subset

External Links

PubMed source DOI: 10.1016/s0969-2126(97)00263-3 View journal details

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