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PMID: 932771 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Intracisternal virus-like particles in brain of a multiple sclerosis patient.

Journal of the neurological sciences ·Vol. 28 ·No. 1 ·1976-05-00 ·Pages 121-6

Tanaka R, Iwasaki Y, Koprowski H

Abstract

Doughnut-shaped particles, 55-65 nm in diameter, were revealed by electron microscopy in the cisterns of the rough endoplasmic reticulum of cells from an active lesion in autopsied brain tissue from a multiple sclerosis patient. The morphology of the particles closely resembled that of coronaviruses.

MeSH Terms
Adult Brain/ultrastructure Coronaviridae/ultrastructure Female Humans Multiple Sclerosis/etiology,microbiology,pathology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Tanaka R
Iwasaki Y
Koprowski H
References (12)
12 references, click to expand
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  9. Ultrastructural studies of parallel tubular arrays in human lymphocytes.
    Am J Pathol. 1975 Jan;78(1):59-70 PMID: 162823
  10. Meningoencephalitis with toroidal virus-like particles.
    Acta Neuropathol. 1975;31(4):273-9 PMID: 1155039
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    Am J Pathol. 1975 Dec;81(3):467-78 PMID: 1211421
  12. Fusion of cultured multiple-sclerosis brain cells with indicator cells: presence of nucleocapsids and virions and isolation of parainfluenza-type virus.
    Lancet. 1972 Jul 1;2(7766):1-5 PMID: 4113621
Article Info
Journal
Journal of the neurological sciences
Abbr.
J Neurol Sci
ISSN
0022-510X
DOI
10.1016/0022-510x(76)90053-8
Published
1976-05-00
Pages
121-6
Language
English
Region
Netherlands
NLM ID
0375403
PMCID
PMC7118424
Subset
IM
External Links
PubMed source DOI: 10.1016/0022-510x(76)90053-8 PMC Full Text View journal details
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